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• W2005639695 abstract "ALG-2 (apoptosis linked gene-2) is an essential protein for the execution of apoptosis whose function is largely unknown. Here, we demonstrate that ALG-2 could interact with the C-terminus (amino acids 941-1375) of the apoptosis signal-regulating kinase 1 (ASK1) in BOSC23 cells as well as in vitro. ASK1 failed to bind to an isotype of ALG-2 found in the liver, ALG-2,1, in which two amino acids (Gly-121 and Phe-122) are deleted. This implies that the interaction is very specific. Cotransfection with ALG-2 resulted in the nuclear presence of ASK1 and inhibited the activation of c-Jun N-terminal kinase (JNK) by ASK1 in BOSC23 cells. This study reports that ALG-2 could regulate the subcellular localization and the JNK activity modulation of ASK1 by direct interaction." @default.
• W2005639695 created "2016-06-24" @default.
• W2005639695 creator A5014132243 @default.
• W2005639695 creator A5016824440 @default.
• W2005639695 creator A5075764936 @default.
• W2005639695 date "2002-09-11" @default.
• W2005639695 modified "2023-09-26" @default.
• W2005639695 title "Interaction of ALG-2 with ASK1 influences ASK1 localization and subsequent JNK activation" @default.
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• W2005639695 doi "https://doi.org/10.1016/s0014-5793(02)03329-x" @default.
• W2005639695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12372597" @default.
• W2005639695 hasPublicationYear "2002" @default.
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