FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005641325> ?p ?o ?g. }

• W2005641325 endingPage "e87769" @default.
• W2005641325 startingPage "e87769" @default.
• W2005641325 abstract "Recent studies have demonstrated that statins reduce cell viability and induce apoptosis in various types of cancer cells. The molecular mechanisms underlying these effects are poorly understood. The JAK/STAT pathway plays an important role in the regulation of proliferation and apoptosis in many tissues, and its deregulation is believed to be involved in tumorigenesis and cancer. The physiological activation of STAT proteins by GH is rapid but transient in nature and its inactivation is regulated mainly by the expression of SOCS proteins. UMR-106 osteosarcoma cells express a GH-responsive JAK2/STAT5 signaling pathway, providing an experimental model to study the influence of statins on this system. In this study we investigated the actions of simvastatin on cell proliferation, migration, and invasion on UMR-106 cells and examined whether alterations in GH-stimulated JAK/STAT/SOCS signaling may be observed. Results showed that treatment of osteosarcoma cells with simvastatin at 3 to 10 µM doses decreases cell proliferation, migration, and invasion in a time- and dose-dependent manner. At the molecular level, although the mechanisms used by simvastatin are not entirely clear, the effect of the statin on the reduction of JAK2 and STAT5 phosphorylation levels may partially explain the decrease in the GH-stimulated STAT5 transcriptional activity. This effect correlated with a time- and dose-dependent increase of SOCS-3 expression levels in cells treated with simvastatin, a regulatory role that has not been previously described. Furthermore, the finding that simvastatin is capable of inducing SOCS-3 and CIS genes expression shows the potential of the JAK/STAT pathway as a therapeutic target, reinforcing the efficacy of simvastatin as chemotherapeutic drug for the treatment of osteosarcoma." @default.
• W2005641325 created "2016-06-24" @default.
• W2005641325 creator A5000537990 @default.
• W2005641325 creator A5032163198 @default.
• W2005641325 creator A5043119241 @default.
• W2005641325 creator A5044131738 @default.
• W2005641325 creator A5049446238 @default.
• W2005641325 creator A5052124461 @default.
• W2005641325 creator A5084133676 @default.
• W2005641325 date "2014-01-29" @default.
• W2005641325 modified "2023-10-12" @default.
• W2005641325 title "Simvastatin Impairs Growth Hormone-Activated Signal Transducer and Activator of Transcription (STAT) Signaling Pathway in UMR-106 Osteosarcoma Cells" @default.
• W2005641325 cites W1668039320 @default.
• W2005641325 cites W1709568328 @default.
• W2005641325 cites W1866222370 @default.
• W2005641325 cites W1964088193 @default.
• W2005641325 cites W1967597978 @default.
• W2005641325 cites W1968638668 @default.
• W2005641325 cites W1972666937 @default.
• W2005641325 cites W1974392769 @default.
• W2005641325 cites W1981504967 @default.
• W2005641325 cites W1981776895 @default.
• W2005641325 cites W1988362962 @default.
• W2005641325 cites W2014420892 @default.
• W2005641325 cites W2015996294 @default.
• W2005641325 cites W2016812288 @default.
• W2005641325 cites W2024282024 @default.
• W2005641325 cites W2025327319 @default.
• W2005641325 cites W2042867060 @default.
• W2005641325 cites W2044219252 @default.
• W2005641325 cites W2055252601 @default.
• W2005641325 cites W2064212960 @default.
• W2005641325 cites W2069656950 @default.
• W2005641325 cites W2071124826 @default.
• W2005641325 cites W2072573450 @default.
• W2005641325 cites W2072703569 @default.
• W2005641325 cites W2079517866 @default.
• W2005641325 cites W2081324929 @default.
• W2005641325 cites W2082965723 @default.
• W2005641325 cites W2083251014 @default.
• W2005641325 cites W2098547698 @default.
• W2005641325 cites W2103885797 @default.
• W2005641325 cites W2108244474 @default.
• W2005641325 cites W2113764711 @default.
• W2005641325 cites W2119596771 @default.
• W2005641325 cites W2130097438 @default.
• W2005641325 cites W2139908772 @default.
• W2005641325 cites W2143993437 @default.
• W2005641325 cites W3147219933 @default.
• W2005641325 doi "https://doi.org/10.1371/journal.pone.0087769" @default.
• W2005641325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3906206" @default.
• W2005641325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24489959" @default.
• W2005641325 hasPublicationYear "2014" @default.
• W2005641325 type Work @default.
• W2005641325 sameAs 2005641325 @default.
• W2005641325 citedByCount "19" @default.
• W2005641325 countsByYear W20056413252015 @default.
• W2005641325 countsByYear W20056413252016 @default.
• W2005641325 countsByYear W20056413252017 @default.
• W2005641325 countsByYear W20056413252018 @default.
• W2005641325 countsByYear W20056413252019 @default.
• W2005641325 countsByYear W20056413252020 @default.
• W2005641325 countsByYear W20056413252021 @default.
• W2005641325 countsByYear W20056413252023 @default.
• W2005641325 crossrefType "journal-article" @default.
• W2005641325 hasAuthorship W2005641325A5000537990 @default.
• W2005641325 hasAuthorship W2005641325A5032163198 @default.
• W2005641325 hasAuthorship W2005641325A5043119241 @default.
• W2005641325 hasAuthorship W2005641325A5044131738 @default.
• W2005641325 hasAuthorship W2005641325A5049446238 @default.
• W2005641325 hasAuthorship W2005641325A5052124461 @default.
• W2005641325 hasAuthorship W2005641325A5084133676 @default.
• W2005641325 hasBestOaLocation W20056413251 @default.
• W2005641325 hasConcept C112392421 @default.
• W2005641325 hasConcept C121608353 @default.
• W2005641325 hasConcept C134018914 @default.
• W2005641325 hasConcept C157333092 @default.
• W2005641325 hasConcept C171958077 @default.
• W2005641325 hasConcept C185592680 @default.
• W2005641325 hasConcept C190283241 @default.
• W2005641325 hasConcept C2776329913 @default.
• W2005641325 hasConcept C2777760704 @default.
• W2005641325 hasConcept C2778277574 @default.
• W2005641325 hasConcept C2778923194 @default.
• W2005641325 hasConcept C2779391668 @default.
• W2005641325 hasConcept C42362537 @default.
• W2005641325 hasConcept C502942594 @default.
• W2005641325 hasConcept C54355233 @default.
• W2005641325 hasConcept C55493867 @default.
• W2005641325 hasConcept C555283112 @default.
• W2005641325 hasConcept C62112901 @default.
• W2005641325 hasConcept C62478195 @default.
• W2005641325 hasConcept C86803240 @default.
• W2005641325 hasConcept C95444343 @default.
• W2005641325 hasConceptScore W2005641325C112392421 @default.
• W2005641325 hasConceptScore W2005641325C121608353 @default.
• W2005641325 hasConceptScore W2005641325C134018914 @default.
• W2005641325 hasConceptScore W2005641325C157333092 @default.

• next