FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005643237> ?p ?o ?g. }

• W2005643237 endingPage "11939" @default.
• W2005643237 startingPage "11934" @default.
• W2005643237 abstract "Salvia divinorum, whose main active ingredient is the neoclerodane diterpene Salvinorin A, is a hallucinogenic plant in the mint family that has been used in traditional spiritual practices for its psychoactive properties by the Mazatecs of Oaxaca, Mexico. More recently, S. divinorum extracts and Salvinorin A have become more widely used in the U.S. as legal hallucinogens. We discovered that Salvinorin A potently and selectively inhibited (3)H-bremazocine binding to cloned kappa opioid receptors. Salvinorin A had no significant activity against a battery of 50 receptors, transporters, and ion channels and showed a distinctive profile compared with the prototypic hallucinogen lysergic acid diethylamide. Functional studies demonstrated that Salvinorin A is a potent kappa opioid agonist at cloned kappa opioid receptors expressed in human embryonic kidney-293 cells and at native kappa opioid receptors expressed in guinea pig brain. Importantly, Salvinorin A had no actions at the 5-HT(2A) serotonin receptor, the principal molecular target responsible for the actions of classical hallucinogens. Salvinorin A thus represents, to our knowledge, the first naturally occurring nonnitrogenous opioid-receptor subtype-selective agonist. Because Salvinorin A is a psychotomimetic selective for kappa opioid receptors, kappa opioid-selective antagonists may represent novel psychotherapeutic compounds for diseases manifested by perceptual distortions (e.g., schizophrenia, dementia, and bipolar disorders). Additionally, these results suggest that kappa opioid receptors play a prominent role in the modulation of human perception." @default.
• W2005643237 created "2016-06-24" @default.
• W2005643237 creator A5007388845 @default.
• W2005643237 creator A5007856961 @default.
• W2005643237 creator A5014751602 @default.
• W2005643237 creator A5018269231 @default.
• W2005643237 creator A5058910529 @default.
• W2005643237 creator A5065763891 @default.
• W2005643237 creator A5072565784 @default.
• W2005643237 creator A5073530283 @default.
• W2005643237 date "2002-08-21" @default.
• W2005643237 modified "2023-09-30" @default.
• W2005643237 title "Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist" @default.
• W2005643237 cites W1482335491 @default.
• W2005643237 cites W1900414416 @default.
• W2005643237 cites W1918269093 @default.
• W2005643237 cites W1936582343 @default.
• W2005643237 cites W1968021269 @default.
• W2005643237 cites W1972160739 @default.
• W2005643237 cites W1973660081 @default.
• W2005643237 cites W1975475397 @default.
• W2005643237 cites W1976480594 @default.
• W2005643237 cites W1982562901 @default.
• W2005643237 cites W1984641010 @default.
• W2005643237 cites W1985833916 @default.
• W2005643237 cites W1986100519 @default.
• W2005643237 cites W1991426892 @default.
• W2005643237 cites W1993291607 @default.
• W2005643237 cites W1996997570 @default.
• W2005643237 cites W2002330441 @default.
• W2005643237 cites W2010531200 @default.
• W2005643237 cites W2016608723 @default.
• W2005643237 cites W2016632496 @default.
• W2005643237 cites W2029846690 @default.
• W2005643237 cites W2030252531 @default.
• W2005643237 cites W2032643119 @default.
• W2005643237 cites W2033680879 @default.
• W2005643237 cites W2043486410 @default.
• W2005643237 cites W2049981218 @default.
• W2005643237 cites W2055222961 @default.
• W2005643237 cites W2056382948 @default.
• W2005643237 cites W2061604677 @default.
• W2005643237 cites W2070794292 @default.
• W2005643237 cites W2073146939 @default.
• W2005643237 cites W2073442562 @default.
• W2005643237 cites W2079106221 @default.
• W2005643237 cites W2081814150 @default.
• W2005643237 cites W2083162388 @default.
• W2005643237 cites W2083661078 @default.
• W2005643237 cites W2091074778 @default.
• W2005643237 cites W2106627591 @default.
• W2005643237 cites W2130472744 @default.
• W2005643237 cites W2144085742 @default.
• W2005643237 cites W2147873829 @default.
• W2005643237 cites W2148208755 @default.
• W2005643237 cites W2149963584 @default.
• W2005643237 cites W2152150798 @default.
• W2005643237 cites W2323627339 @default.
• W2005643237 cites W2426006819 @default.
• W2005643237 cites W2437983647 @default.
• W2005643237 cites W2893773162 @default.
• W2005643237 cites W2916587069 @default.
• W2005643237 cites W2952887070 @default.
• W2005643237 doi "https://doi.org/10.1073/pnas.182234399" @default.
• W2005643237 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/129372" @default.
• W2005643237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12192085" @default.
• W2005643237 hasPublicationYear "2002" @default.
• W2005643237 type Work @default.
• W2005643237 sameAs 2005643237 @default.
• W2005643237 citedByCount "682" @default.
• W2005643237 countsByYear W20056432372012 @default.
• W2005643237 countsByYear W20056432372013 @default.
• W2005643237 countsByYear W20056432372014 @default.
• W2005643237 countsByYear W20056432372015 @default.
• W2005643237 countsByYear W20056432372016 @default.
• W2005643237 countsByYear W20056432372017 @default.
• W2005643237 countsByYear W20056432372018 @default.
• W2005643237 countsByYear W20056432372019 @default.
• W2005643237 countsByYear W20056432372020 @default.
• W2005643237 countsByYear W20056432372021 @default.
• W2005643237 countsByYear W20056432372022 @default.
• W2005643237 countsByYear W20056432372023 @default.
• W2005643237 crossrefType "journal-article" @default.
• W2005643237 hasAuthorship W2005643237A5007388845 @default.
• W2005643237 hasAuthorship W2005643237A5007856961 @default.
• W2005643237 hasAuthorship W2005643237A5014751602 @default.
• W2005643237 hasAuthorship W2005643237A5018269231 @default.
• W2005643237 hasAuthorship W2005643237A5058910529 @default.
• W2005643237 hasAuthorship W2005643237A5065763891 @default.
• W2005643237 hasAuthorship W2005643237A5072565784 @default.
• W2005643237 hasAuthorship W2005643237A5073530283 @default.
• W2005643237 hasBestOaLocation W20056432371 @default.
• W2005643237 hasConcept C124315065 @default.
• W2005643237 hasConcept C170493617 @default.
• W2005643237 hasConcept C184389661 @default.
• W2005643237 hasConcept C185592680 @default.
• W2005643237 hasConcept C2778938600 @default.
• W2005643237 hasConcept C2781063702 @default.

• next