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- W2005651569 abstract "The effect of DNAase I on the synthesis of poly(ADP-ribose) by HeLa nuclei was studied. Experiments with the isolated products showed that the addition of DNAase I to the complete reaction mixture increased the chain length of the isolated product, poly(ADP-ribose), by only 10–20%. This small increase cannot account for the 400–600% increase in poly(ADP-ribose) polymerase activity that is seen when DNAase I is added to the assay media. So these results indicate that the main effect of DNAase I on the synthesis of poly(ADP-ribose) is through the initiation of new chains of poly(ADP-ribose). This evidence supports the idea that poly(ADP-ribose) polymerase may have a role in DNA repair." @default.
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- W2005651569 date "1975-09-01" @default.
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- W2005651569 title "Effect of deoxyribonuclease I on the number and length of chains of poly(ADP-ribose) synthesized, in vitro" @default.
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- W2005651569 doi "https://doi.org/10.1016/s0006-291x(75)80325-1" @default.
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