FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005652264> ?p ?o ?g. }

• W2005652264 endingPage "49" @default.
• W2005652264 startingPage "39" @default.
• W2005652264 abstract "Neocortical synapses display several forms of short-term plasticity including paired-pulse facilitation and depression. The mechanisms underlying this diversity are unclear. Synaptic currents in response to paired stimulation were recorded from layer II/III pyramidal neurons in rat frontal neocortical slices using the whole-cell patch-clamp method. Both paired-pulse facilitation (PPF) and paired-pulse depression (PPD) were observed in control saline. In the presence of 10 microM bicuculline (BIC), prominent PPD was consistently elicited. The maximal depression of the second EPSC occurred around 100 ms although PPD was still observed at intervals up to 1500 ms. Manipulations that reduced the probability of transmitter release significantly affected PPD. Both conditioning (C)- and test (T)-EPSCs were reduced when the extracellular Ca(2+) concentration was lowered from 3 to 1 mM. The decrease was greater in the C-EPSC resulting in a decrease in PPD. The gamma-aminobutyric acid (GABA)(B) receptor agonist baclofen (10 microM) reduced the amplitude of both evoked EPSCs and changed PPD to PPF. In the presence of the GABA(B) antagonists 2(OH)-saclofen (200-400 microM) or SCH50911 (10 microM), PPF was commonly observed. The metabotropic glutamate receptor antagonist MCPG (500 microM) had no effect on neocortical PPD. Brief stimulus trains induced a progressive depression that was insensitive to GABA(B) antagonists. Paired-pulse depression of excitatory synaptic transmission is a prominent phenomenon in frontal neocortex. At least two components of depression were observed. They may play an important role in regulating the balance between excitation and inhibition, therefore maintaining stability in cortical circuits." @default.
• W2005652264 created "2016-06-24" @default.
• W2005652264 creator A5006128923 @default.
• W2005652264 creator A5071337074 @default.
• W2005652264 date "2003-01-01" @default.
• W2005652264 modified "2023-10-17" @default.
• W2005652264 title "GABAB receptor-mediated heterosynaptic depression of excitatory synaptic transmission in rat frontal neocortex" @default.
• W2005652264 cites W1497597874 @default.
• W2005652264 cites W1558862799 @default.
• W2005652264 cites W1571745125 @default.
• W2005652264 cites W1595843790 @default.
• W2005652264 cites W1762877386 @default.
• W2005652264 cites W180111337 @default.
• W2005652264 cites W1856380311 @default.
• W2005652264 cites W1877020112 @default.
• W2005652264 cites W1927932324 @default.
• W2005652264 cites W1964051333 @default.
• W2005652264 cites W1969319931 @default.
• W2005652264 cites W1970161814 @default.
• W2005652264 cites W1973028934 @default.
• W2005652264 cites W1988007470 @default.
• W2005652264 cites W1991999672 @default.
• W2005652264 cites W1992679778 @default.
• W2005652264 cites W1993861337 @default.
• W2005652264 cites W1994520251 @default.
• W2005652264 cites W1996805443 @default.
• W2005652264 cites W1999772445 @default.
• W2005652264 cites W2000964053 @default.
• W2005652264 cites W2001833774 @default.
• W2005652264 cites W2001860569 @default.
• W2005652264 cites W2003542304 @default.
• W2005652264 cites W2007629000 @default.
• W2005652264 cites W2014167862 @default.
• W2005652264 cites W2020917920 @default.
• W2005652264 cites W2021459769 @default.
• W2005652264 cites W2021897528 @default.
• W2005652264 cites W2023654689 @default.
• W2005652264 cites W2036236793 @default.
• W2005652264 cites W2037593266 @default.
• W2005652264 cites W2039075215 @default.
• W2005652264 cites W2043123579 @default.
• W2005652264 cites W2046023579 @default.
• W2005652264 cites W2071161962 @default.
• W2005652264 cites W2071684215 @default.
• W2005652264 cites W2073799926 @default.
• W2005652264 cites W2079283223 @default.
• W2005652264 cites W2089007590 @default.
• W2005652264 cites W2091227420 @default.
• W2005652264 cites W2100662386 @default.
• W2005652264 cites W2102268999 @default.
• W2005652264 cites W2102574599 @default.
• W2005652264 cites W2109374914 @default.
• W2005652264 cites W2110258654 @default.
• W2005652264 cites W2119885696 @default.
• W2005652264 cites W2119989547 @default.
• W2005652264 cites W2126717163 @default.
• W2005652264 cites W2130203263 @default.
• W2005652264 cites W2134348865 @default.
• W2005652264 cites W2156780983 @default.
• W2005652264 cites W2165544326 @default.
• W2005652264 cites W2166740761 @default.
• W2005652264 cites W2226243321 @default.
• W2005652264 cites W2285208598 @default.
• W2005652264 cites W2291393583 @default.
• W2005652264 cites W2412056671 @default.
• W2005652264 cites W2473065263 @default.
• W2005652264 cites W3021526609 @default.
• W2005652264 cites W4233987775 @default.
• W2005652264 cites W4298284983 @default.
• W2005652264 doi "https://doi.org/10.1016/s0006-8993(02)03720-4" @default.
• W2005652264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12480156" @default.
• W2005652264 hasPublicationYear "2003" @default.
• W2005652264 type Work @default.
• W2005652264 sameAs 2005652264 @default.
• W2005652264 citedByCount "18" @default.
• W2005652264 countsByYear W20056522642013 @default.
• W2005652264 countsByYear W20056522642014 @default.
• W2005652264 countsByYear W20056522642015 @default.
• W2005652264 countsByYear W20056522642017 @default.
• W2005652264 countsByYear W20056522642019 @default.
• W2005652264 crossrefType "journal-article" @default.
• W2005652264 hasAuthorship W2005652264A5006128923 @default.
• W2005652264 hasAuthorship W2005652264A5071337074 @default.
• W2005652264 hasConcept C101027131 @default.
• W2005652264 hasConcept C112592302 @default.
• W2005652264 hasConcept C134018914 @default.
• W2005652264 hasConcept C168258287 @default.
• W2005652264 hasConcept C169760540 @default.
• W2005652264 hasConcept C170493617 @default.
• W2005652264 hasConcept C17077164 @default.
• W2005652264 hasConcept C185592680 @default.
• W2005652264 hasConcept C200170125 @default.
• W2005652264 hasConcept C2777222312 @default.
• W2005652264 hasConcept C2778938600 @default.
• W2005652264 hasConcept C2780763569 @default.
• W2005652264 hasConcept C29561615 @default.
• W2005652264 hasConcept C55493867 @default.
• W2005652264 hasConcept C61174792 @default.

• next