Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005654751> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2005654751 abstract "Depolarisation of ischaemic myocardial cells is at least partly due to loss of cellular potassium. Whereas most manifestations of ischaemia vary with heart rate potassium loss, however, reportedly does not. Cellular depolarisation was therefore correlated with extracellular potassium activity during serial coronary artery occlusions in Langendorff perfused canine hearts. Occlusions in sinus rhythm (92(11) beats X min-1) were alternated with rapidly paced occlusions (180 beats X min-1). For each occlusion cellular depolarisation was estimated from TQ depression and compared with the simultaneous increase in potassium electrode potential, delta EK. Although potassium accumulation accounted for most of the estimated depolarisation at slow heart rates, a potassium independent mechanism predominated during rapid pacing. The potassium independent mechanism was especially important in the first minute of ischaemia when pacing increased depolarisation by 324%, with little increase in delta EK. It appears that ischaemia induces a rate sensitive depolarising membrane current, which worsens conduction and promotes arrhythmias." @default.
- W2005654751 created "2016-06-24" @default.
- W2005654751 creator A5032393137 @default.
- W2005654751 creator A5060689783 @default.
- W2005654751 creator A5071647718 @default.
- W2005654751 date "1986-08-01" @default.
- W2005654751 modified "2023-09-26" @default.
- W2005654751 title "Rate dependence of ischaemic myocardial depolarisation: evidence for a novel membrane current" @default.
- W2005654751 doi "https://doi.org/10.1093/cvr/20.8.557" @default.
- W2005654751 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3791344" @default.
- W2005654751 hasPublicationYear "1986" @default.
- W2005654751 type Work @default.
- W2005654751 sameAs 2005654751 @default.
- W2005654751 citedByCount "12" @default.
- W2005654751 countsByYear W20056547512015 @default.
- W2005654751 crossrefType "journal-article" @default.
- W2005654751 hasAuthorship W2005654751A5032393137 @default.
- W2005654751 hasAuthorship W2005654751A5060689783 @default.
- W2005654751 hasAuthorship W2005654751A5071647718 @default.
- W2005654751 hasConcept C126322002 @default.
- W2005654751 hasConcept C164705383 @default.
- W2005654751 hasConcept C178790620 @default.
- W2005654751 hasConcept C181911157 @default.
- W2005654751 hasConcept C185592680 @default.
- W2005654751 hasConcept C2777953023 @default.
- W2005654751 hasConcept C2780393670 @default.
- W2005654751 hasConcept C4141045 @default.
- W2005654751 hasConcept C42219234 @default.
- W2005654751 hasConcept C517785266 @default.
- W2005654751 hasConcept C541997718 @default.
- W2005654751 hasConcept C55493867 @default.
- W2005654751 hasConcept C71924100 @default.
- W2005654751 hasConcept C83743174 @default.
- W2005654751 hasConcept C84393581 @default.
- W2005654751 hasConceptScore W2005654751C126322002 @default.
- W2005654751 hasConceptScore W2005654751C164705383 @default.
- W2005654751 hasConceptScore W2005654751C178790620 @default.
- W2005654751 hasConceptScore W2005654751C181911157 @default.
- W2005654751 hasConceptScore W2005654751C185592680 @default.
- W2005654751 hasConceptScore W2005654751C2777953023 @default.
- W2005654751 hasConceptScore W2005654751C2780393670 @default.
- W2005654751 hasConceptScore W2005654751C4141045 @default.
- W2005654751 hasConceptScore W2005654751C42219234 @default.
- W2005654751 hasConceptScore W2005654751C517785266 @default.
- W2005654751 hasConceptScore W2005654751C541997718 @default.
- W2005654751 hasConceptScore W2005654751C55493867 @default.
- W2005654751 hasConceptScore W2005654751C71924100 @default.
- W2005654751 hasConceptScore W2005654751C83743174 @default.
- W2005654751 hasConceptScore W2005654751C84393581 @default.
- W2005654751 hasLocation W20056547511 @default.
- W2005654751 hasLocation W20056547512 @default.
- W2005654751 hasOpenAccess W2005654751 @default.
- W2005654751 hasPrimaryLocation W20056547511 @default.
- W2005654751 hasRelatedWork W1967648793 @default.
- W2005654751 hasRelatedWork W1994630059 @default.
- W2005654751 hasRelatedWork W2005654751 @default.
- W2005654751 hasRelatedWork W2020814772 @default.
- W2005654751 hasRelatedWork W2024684114 @default.
- W2005654751 hasRelatedWork W2027704309 @default.
- W2005654751 hasRelatedWork W2034595413 @default.
- W2005654751 hasRelatedWork W2155353284 @default.
- W2005654751 hasRelatedWork W2367095393 @default.
- W2005654751 hasRelatedWork W2426433563 @default.
- W2005654751 isParatext "false" @default.
- W2005654751 isRetracted "false" @default.
- W2005654751 magId "2005654751" @default.
- W2005654751 workType "article" @default.