FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005655317> ?p ?o ?g. }

• W2005655317 endingPage "2309" @default.
• W2005655317 startingPage "2299" @default.
• W2005655317 abstract "To report baseline data on 180 patients with Wegener's granulomatosis (WG) enrolled in the WG Etanercept Trial (WGET), and to examine demographic and clinical differences between patients with limited disease and those with severe disease.Definitions of limited and severe disease were agreed upon by consensus of the investigators at a pretrial meeting and were incorporated into the protocol as a stratification criterion. These data were applied prospectively to the WGET patient cohort, based on clinical features and the intention to treat patients according to disease activity. Data related to disease onset, date of diagnosis, clinical features, antineutrophil cytoplasmic antibody assays, tissue biopsy findings, and other medical history were collected on a baseline medical history form. Physician-investigators from each center participated in the development of this form, and all were certified in its use prior to the start of the trial. Selected data on patients who were screened for the trial but were not enrolled were also collected.Several significant differences between the limited and severe disease subsets were observed. Patients with limited disease were nearly a decade younger at disease onset compared with patients with severe disease. Thirty-three percent of patients with severe disease were women, compared with 58% of those with limited disease. Despite their younger age at symptom onset, patients with limited disease tended to have longer disease duration, a greater likelihood of experiencing exacerbation of previous disease following a period of remission, and a higher prevalence of destructive upper respiratory tract disorders at the time of enrollment (e.g., saddle-nose deformity). Patients with limited WG were less likely than those with severe disease to have antibodies to either proteinase 3 or myeloperoxidase. Patients with severe disease had a higher likelihood of previous thyroid disease, particularly either Graves' disease or Hashimoto thyroiditis, suggesting the possibility of different pathogenetic factors within these disease subsets. Other observed differences between these subsets, such as the greater frequency of alveolar hemorrhage in the severe disease group, were related to the a priori definitions of limited and severe disease.There are significant differences between patients with limited WG and those with severe WG with regard to sex, age, the likelihood of recurrent disease, the risk of damage in certain organ systems, and, possibly, etiologic factors. These differences (and perhaps other differences that are currently unrecognized) in patient subsets may have implications for mechanisms of pathogenesis, prognosis, response to treatment, and the design of future clinical investigations." @default.
• W2005655317 created "2016-06-24" @default.
• W2005655317 creator A5042482253 @default.
• W2005655317 date "2003-08-01" @default.
• W2005655317 modified "2023-10-14" @default.
• W2005655317 title "Limited versus severe Wegener's granulomatosis: Baseline data on patients in the Wegener's granulomatosis etanercept trial" @default.
• W2005655317 cites W1908543567 @default.
• W2005655317 cites W1957383308 @default.
• W2005655317 cites W1965349553 @default.
• W2005655317 cites W1982860902 @default.
• W2005655317 cites W1985591373 @default.
• W2005655317 cites W1989727528 @default.
• W2005655317 cites W1999520120 @default.
• W2005655317 cites W2011309580 @default.
• W2005655317 cites W2012850200 @default.
• W2005655317 cites W2014128625 @default.
• W2005655317 cites W2017990928 @default.
• W2005655317 cites W2027813785 @default.
• W2005655317 cites W2034259145 @default.
• W2005655317 cites W2053329959 @default.
• W2005655317 cites W2055896786 @default.
• W2005655317 cites W2058540485 @default.
• W2005655317 cites W2070655720 @default.
• W2005655317 cites W2071333258 @default.
• W2005655317 cites W2073208829 @default.
• W2005655317 cites W2083777349 @default.
• W2005655317 cites W2094386684 @default.
• W2005655317 cites W2094935007 @default.
• W2005655317 cites W2096919147 @default.
• W2005655317 cites W2101093436 @default.
• W2005655317 cites W2109207289 @default.
• W2005655317 cites W2117622761 @default.
• W2005655317 cites W2127067744 @default.
• W2005655317 cites W2131195925 @default.
• W2005655317 cites W2133547068 @default.
• W2005655317 cites W2142627411 @default.
• W2005655317 cites W2148113299 @default.
• W2005655317 cites W2161351394 @default.
• W2005655317 cites W2163488378 @default.
• W2005655317 cites W2164963321 @default.
• W2005655317 cites W2171950933 @default.
• W2005655317 cites W2495844243 @default.
• W2005655317 cites W2989500980 @default.
• W2005655317 doi "https://doi.org/10.1002/art.11075" @default.
• W2005655317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12905485" @default.
• W2005655317 hasPublicationYear "2003" @default.
• W2005655317 type Work @default.
• W2005655317 sameAs 2005655317 @default.
• W2005655317 citedByCount "363" @default.
• W2005655317 countsByYear W20056553172012 @default.
• W2005655317 countsByYear W20056553172013 @default.
• W2005655317 countsByYear W20056553172014 @default.
• W2005655317 countsByYear W20056553172015 @default.
• W2005655317 countsByYear W20056553172016 @default.
• W2005655317 countsByYear W20056553172017 @default.
• W2005655317 countsByYear W20056553172018 @default.
• W2005655317 countsByYear W20056553172019 @default.
• W2005655317 countsByYear W20056553172020 @default.
• W2005655317 countsByYear W20056553172021 @default.
• W2005655317 countsByYear W20056553172022 @default.
• W2005655317 countsByYear W20056553172023 @default.
• W2005655317 crossrefType "journal-article" @default.
• W2005655317 hasAuthorship W2005655317A5042482253 @default.
• W2005655317 hasBestOaLocation W20056553171 @default.
• W2005655317 hasConcept C126322002 @default.
• W2005655317 hasConcept C141071460 @default.
• W2005655317 hasConcept C1862650 @default.
• W2005655317 hasConcept C187212893 @default.
• W2005655317 hasConcept C2777014857 @default.
• W2005655317 hasConcept C2777226972 @default.
• W2005655317 hasConcept C2777575956 @default.
• W2005655317 hasConcept C2779134260 @default.
• W2005655317 hasConcept C535046627 @default.
• W2005655317 hasConcept C71924100 @default.
• W2005655317 hasConcept C72563966 @default.
• W2005655317 hasConceptScore W2005655317C126322002 @default.
• W2005655317 hasConceptScore W2005655317C141071460 @default.
• W2005655317 hasConceptScore W2005655317C1862650 @default.
• W2005655317 hasConceptScore W2005655317C187212893 @default.
• W2005655317 hasConceptScore W2005655317C2777014857 @default.
• W2005655317 hasConceptScore W2005655317C2777226972 @default.
• W2005655317 hasConceptScore W2005655317C2777575956 @default.
• W2005655317 hasConceptScore W2005655317C2779134260 @default.
• W2005655317 hasConceptScore W2005655317C535046627 @default.
• W2005655317 hasConceptScore W2005655317C71924100 @default.
• W2005655317 hasConceptScore W2005655317C72563966 @default.
• W2005655317 hasIssue "8" @default.
• W2005655317 hasLocation W20056553171 @default.
• W2005655317 hasLocation W20056553172 @default.
• W2005655317 hasOpenAccess W2005655317 @default.
• W2005655317 hasPrimaryLocation W20056553171 @default.
• W2005655317 hasRelatedWork W1873402014 @default.
• W2005655317 hasRelatedWork W2043275298 @default.
• W2005655317 hasRelatedWork W2161750495 @default.
• W2005655317 hasRelatedWork W2200007585 @default.
• W2005655317 hasRelatedWork W2401433933 @default.
• W2005655317 hasRelatedWork W2404101318 @default.
• W2005655317 hasRelatedWork W2612262933 @default.

• next