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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005657478> ?p ?o ?g. }

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• W2005657478 abstract "This work describes the synthesis and characterization of four new ligands derived from 1,3-propanediamine in addition to the preparation and characterization of their respective platinum(II) complexes by reaction with K2PtCl4. These ligands were obtained by the reaction of the corresponding alkyl mesylate with 1,3-propanediamine. We have prepared compounds having different carbon chains lengths in an attempt to correlate this factor, which influences the lipophilicity of the compounds, with cytotoxic activity. Octanol/water partition coefficients, the effect of the four complexes on the growth of two tumoral cell lines, and their cellular uptake were investigated. Increasing lipophilicity enhances the rate of cellular uptake and, consequently, the cytotoxic activity." @default.
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• W2005657478 date "2008-04-01" @default.
• W2005657478 modified "2023-10-17" @default.
• W2005657478 title "Impact of the carbon chain length of novel platinum complexes derived from N-alkyl-propanediamines on their cytotoxic activity and cellular uptake" @default.
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• W2005657478 doi "https://doi.org/10.1016/j.jinorgbio.2007.11.013" @default.
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