FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005661646> ?p ?o ?g. }

• W2005661646 endingPage "129" @default.
• W2005661646 startingPage "118" @default.
• W2005661646 abstract "The amino acid sequences of the α subunits of tryptophan synthase form ten different microorganisms were alingned by standard procedures. The α helics, β strands and turns of each sequence were predicted separately by two standard prediction algorithms and averaged at homologous sequence positions. Additional evidence for conserved secondary structure was derived form profiles of average hydropathy and chain flexibility values, leading to a joint prediction. There is good agreement between (1) predicted β strands, maximal hydropathy and minimal flexibility, and (2) predicted loops, great chain flexibility, and protein segments that accept insertions of various lengths in individual sequences. The α subunit is predicted to have eight repeated β-loop-α-loop motifs with an extra N-terminal α helix and an intercalated segment of highly conserved residues. This pattern suggests that the teritiary structure of the α subunit is an eightfold α/β barrel. The distribution of conserved amino acid residues and publilshed data on limited proteolysis, chemical modification, and mutagenesis are consistent with the α/β barrel structure. Both the active site of the α subunit and the combining site for the β2 subunit are at the end of the barrel formed by the carboxyl-termini of the β strands." @default.
• W2005661646 created "2016-06-24" @default.
• W2005661646 creator A5027224579 @default.
• W2005661646 creator A5035201213 @default.
• W2005661646 creator A5059235587 @default.
• W2005661646 date "1987-01-01" @default.
• W2005661646 modified "2023-10-15" @default.
• W2005661646 title "Prediction of secondary structure by evolutionary comparison: Application to the α subunit of tryptophan synthase" @default.
• W2005661646 cites W135160761 @default.
• W2005661646 cites W1493866128 @default.
• W2005661646 cites W1508885706 @default.
• W2005661646 cites W1518942907 @default.
• W2005661646 cites W1519698205 @default.
• W2005661646 cites W1533883995 @default.
• W2005661646 cites W1541354727 @default.
• W2005661646 cites W1572097599 @default.
• W2005661646 cites W1584811853 @default.
• W2005661646 cites W1608161264 @default.
• W2005661646 cites W1648048768 @default.
• W2005661646 cites W178856931 @default.
• W2005661646 cites W1967019660 @default.
• W2005661646 cites W1973476721 @default.
• W2005661646 cites W1975304761 @default.
• W2005661646 cites W1975818527 @default.
• W2005661646 cites W1979081881 @default.
• W2005661646 cites W1981493249 @default.
• W2005661646 cites W1982903160 @default.
• W2005661646 cites W1989447327 @default.
• W2005661646 cites W1991229978 @default.
• W2005661646 cites W1991942374 @default.
• W2005661646 cites W2009500272 @default.
• W2005661646 cites W2010919933 @default.
• W2005661646 cites W2016339621 @default.
• W2005661646 cites W2022465390 @default.
• W2005661646 cites W2023124828 @default.
• W2005661646 cites W2036557038 @default.
• W2005661646 cites W2044831294 @default.
• W2005661646 cites W2049695588 @default.
• W2005661646 cites W2052895607 @default.
• W2005661646 cites W2056619794 @default.
• W2005661646 cites W2056672240 @default.
• W2005661646 cites W2061197399 @default.
• W2005661646 cites W2069136826 @default.
• W2005661646 cites W2069469909 @default.
• W2005661646 cites W2073925106 @default.
• W2005661646 cites W2074231493 @default.
• W2005661646 cites W2081516433 @default.
• W2005661646 cites W2087202599 @default.
• W2005661646 cites W2089936282 @default.
• W2005661646 cites W2091642257 @default.
• W2005661646 cites W2092045508 @default.
• W2005661646 cites W2095450147 @default.
• W2005661646 cites W2123333780 @default.
• W2005661646 cites W2142420001 @default.
• W2005661646 cites W2161002018 @default.
• W2005661646 cites W223173673 @default.
• W2005661646 doi "https://doi.org/10.1002/prot.340020206" @default.
• W2005661646 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3328860" @default.
• W2005661646 hasPublicationYear "1987" @default.
• W2005661646 type Work @default.
• W2005661646 sameAs 2005661646 @default.
• W2005661646 citedByCount "133" @default.
• W2005661646 countsByYear W20056616462014 @default.
• W2005661646 countsByYear W20056616462017 @default.
• W2005661646 countsByYear W20056616462018 @default.
• W2005661646 crossrefType "journal-article" @default.
• W2005661646 hasAuthorship W2005661646A5027224579 @default.
• W2005661646 hasAuthorship W2005661646A5035201213 @default.
• W2005661646 hasAuthorship W2005661646A5059235587 @default.
• W2005661646 hasConcept C104292427 @default.
• W2005661646 hasConcept C104317684 @default.
• W2005661646 hasConcept C167625842 @default.
• W2005661646 hasConcept C185592680 @default.
• W2005661646 hasConcept C2776706248 @default.
• W2005661646 hasConcept C2779882130 @default.
• W2005661646 hasConcept C47701112 @default.
• W2005661646 hasConcept C515207424 @default.
• W2005661646 hasConcept C55493867 @default.
• W2005661646 hasConcept C62614982 @default.
• W2005661646 hasConcept C86803240 @default.
• W2005661646 hasConceptScore W2005661646C104292427 @default.
• W2005661646 hasConceptScore W2005661646C104317684 @default.
• W2005661646 hasConceptScore W2005661646C167625842 @default.
• W2005661646 hasConceptScore W2005661646C185592680 @default.
• W2005661646 hasConceptScore W2005661646C2776706248 @default.
• W2005661646 hasConceptScore W2005661646C2779882130 @default.
• W2005661646 hasConceptScore W2005661646C47701112 @default.
• W2005661646 hasConceptScore W2005661646C515207424 @default.
• W2005661646 hasConceptScore W2005661646C55493867 @default.
• W2005661646 hasConceptScore W2005661646C62614982 @default.
• W2005661646 hasConceptScore W2005661646C86803240 @default.
• W2005661646 hasIssue "2" @default.
• W2005661646 hasLocation W20056616461 @default.
• W2005661646 hasLocation W20056616462 @default.
• W2005661646 hasOpenAccess W2005661646 @default.
• W2005661646 hasPrimaryLocation W20056616461 @default.
• W2005661646 hasRelatedWork W1615821836 @default.
• W2005661646 hasRelatedWork W1966123072 @default.

• next