Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005661665> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2005661665 endingPage "73" @default.
- W2005661665 startingPage "70" @default.
- W2005661665 abstract "Digoxin kinetics are substantially altered by quinidine and by spironolactone. We evaluated the effect of the combination of quinidine and spironolactone on digoxin kinetics and compared it to the effect on digoxin of each drug alone. Six normal subjects each received a 1.0-mg intravenous dose of digoxin alone, digoxin with quinidine, digoxin with spironolactone, and digoxin with both quinidine and spironolactone. Spironolactone and quinidine, alone and in combination, reduced digoxin systemic, renal, and nonrenal clearances and prolonged digoxin elimination t½. A greater alteration in digoxin kinetics was induced by quinidine than by spironolactone, and an even greater effect resulted from the combination. We did not assess clinical consequences of the interaction. We advise reduction in digoxin dose, careful clinical evaluation, and measurement of serum digoxin concentrations when digoxin is used in combination with quinidine and spironolactone. Clinical Pharmacology and Therapeutics (1984) 36, 70–73; doi:10.1038/clpt.1984.141" @default.
- W2005661665 created "2016-06-24" @default.
- W2005661665 creator A5003785349 @default.
- W2005661665 creator A5007573855 @default.
- W2005661665 creator A5090906334 @default.
- W2005661665 date "1984-07-01" @default.
- W2005661665 modified "2023-10-14" @default.
- W2005661665 title "Digoxin-quinidine-spironolactone interaction" @default.
- W2005661665 doi "https://doi.org/10.1038/clpt.1984.141" @default.
- W2005661665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6734052" @default.
- W2005661665 hasPublicationYear "1984" @default.
- W2005661665 type Work @default.
- W2005661665 sameAs 2005661665 @default.
- W2005661665 citedByCount "35" @default.
- W2005661665 countsByYear W20056616652012 @default.
- W2005661665 countsByYear W20056616652013 @default.
- W2005661665 countsByYear W20056616652016 @default.
- W2005661665 countsByYear W20056616652017 @default.
- W2005661665 countsByYear W20056616652018 @default.
- W2005661665 countsByYear W20056616652019 @default.
- W2005661665 countsByYear W20056616652020 @default.
- W2005661665 countsByYear W20056616652021 @default.
- W2005661665 countsByYear W20056616652022 @default.
- W2005661665 countsByYear W20056616652023 @default.
- W2005661665 crossrefType "journal-article" @default.
- W2005661665 hasAuthorship W2005661665A5003785349 @default.
- W2005661665 hasAuthorship W2005661665A5007573855 @default.
- W2005661665 hasAuthorship W2005661665A5090906334 @default.
- W2005661665 hasConcept C126322002 @default.
- W2005661665 hasConcept C185592680 @default.
- W2005661665 hasConcept C2776379505 @default.
- W2005661665 hasConcept C2777707475 @default.
- W2005661665 hasConcept C2778198053 @default.
- W2005661665 hasConcept C2780035454 @default.
- W2005661665 hasConcept C2780339425 @default.
- W2005661665 hasConcept C71924100 @default.
- W2005661665 hasConcept C97320921 @default.
- W2005661665 hasConcept C98274493 @default.
- W2005661665 hasConceptScore W2005661665C126322002 @default.
- W2005661665 hasConceptScore W2005661665C185592680 @default.
- W2005661665 hasConceptScore W2005661665C2776379505 @default.
- W2005661665 hasConceptScore W2005661665C2777707475 @default.
- W2005661665 hasConceptScore W2005661665C2778198053 @default.
- W2005661665 hasConceptScore W2005661665C2780035454 @default.
- W2005661665 hasConceptScore W2005661665C2780339425 @default.
- W2005661665 hasConceptScore W2005661665C71924100 @default.
- W2005661665 hasConceptScore W2005661665C97320921 @default.
- W2005661665 hasConceptScore W2005661665C98274493 @default.
- W2005661665 hasIssue "1" @default.
- W2005661665 hasLocation W20056616651 @default.
- W2005661665 hasLocation W20056616652 @default.
- W2005661665 hasOpenAccess W2005661665 @default.
- W2005661665 hasPrimaryLocation W20056616651 @default.
- W2005661665 hasRelatedWork W191821772 @default.
- W2005661665 hasRelatedWork W1977326434 @default.
- W2005661665 hasRelatedWork W1985799882 @default.
- W2005661665 hasRelatedWork W2005661665 @default.
- W2005661665 hasRelatedWork W2011741742 @default.
- W2005661665 hasRelatedWork W2076875643 @default.
- W2005661665 hasRelatedWork W2244790197 @default.
- W2005661665 hasRelatedWork W2500981404 @default.
- W2005661665 hasRelatedWork W2801822953 @default.
- W2005661665 hasRelatedWork W4240308030 @default.
- W2005661665 hasVolume "36" @default.
- W2005661665 isParatext "false" @default.
- W2005661665 isRetracted "false" @default.
- W2005661665 magId "2005661665" @default.
- W2005661665 workType "article" @default.