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- W2005663256 abstract "We analysed the distribution of genotypes of two polymorphisms in the urokinase-type plasminogen activator (uPA) gene: C-->T substitution in exon 6 and T-->C substitution in intron 7 in 52 subjects with colorectal cancer. Genotypes were determined in tumour tissue and distant mucosa samples by allele-specific polymerase chain reaction. The antigen levels of uPA in cancer tissue were higher than in distant mucosa as measured by enzyme-linked immunosorbent assay. The level of uPA antigens in cancer samples with the C/C genotype of C-->T polymorphism in exon 6 was higher than in samples with C/T and T/T genotypes. No differences in the level of uPA antigens between the alleles of the intron 7 T-->C polymorphism were found. As uPA can be involved in cancer invasion and metastasis, C/C genotype in exon 6 of uPA gene can be further considered as being related to colorectal cancer progression." @default.
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- W2005663256 date "2002-07-01" @default.
- W2005663256 modified "2023-09-26" @default.
- W2005663256 title "Antigen levels of the urokinase-type plasminogen activator and its gene polymorphisms in colorectal cancer" @default.
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- W2005663256 doi "https://doi.org/10.1016/s0304-3835(02)00038-1" @default.
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