FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005667069> ?p ?o ?g. }

• W2005667069 endingPage "1010" @default.
• W2005667069 startingPage "1003" @default.
• W2005667069 abstract "The prognosis of pancreatic cancer is still very poor. No specific effective gene therapy for pancreatic cancer has been found. As a key enzyme of the metabolic process of arachidonic acid, cyclooxygenase-2 (COX-2) has been found to be closely related to the tumorigenesis of epithelial cancers. However, the antitumor effect of small interfering RNA (siRNA) targeting COX-2 in pancreatic cancer has not yet been verified. Therefore, the aim of this study was to investigate the effects of COX-2 gene silencing by siRNA on cell proliferation, cell apoptosis, cell cycle and tumorigenicity of pancreatic cancer cells. COX-2 mRNA was detected by RT-PCR and real-time PCR. COX-2 protein was detected by Western blotting. The cell proliferation was measured by cell counting using microscopy. The cell apoptosis and cell cycle were measured by flow cytometry. The tumorigenicity of Capan-2 pancreatic cancer cells transfected with COX-2 siRNA was evaluated using a nude mouse xenograft model. The expression of COX-2 mRNA as well as COX-2 protein were downregulated after COX-2 siRNA transfection. COX-2 siRNA could inhibit the growth of Capan-2 cells significantly by decreasing the cell proliferation, increasing cell apoptosis and regulating cell cycle as well. In vivo experiments demonstrated that the mean volume and weight of subcutaneous xenografts in nude mice derived from Capan-2 cells transfected with COX-2 siRNA were significantly decreased. COX-2 siRNA could inhibit the growth of Capan-2 pancreatic cancer cells and also decrease the tumorigenicity of Capan-2 cells, implicating a new potential therapeutic target in pancreatic cancer." @default.
• W2005667069 created "2016-06-24" @default.
• W2005667069 creator A5009655674 @default.
• W2005667069 creator A5015722840 @default.
• W2005667069 creator A5065316840 @default.
• W2005667069 creator A5080125836 @default.
• W2005667069 creator A5089812784 @default.
• W2005667069 date "2011-12-19" @default.
• W2005667069 modified "2023-10-01" @default.
• W2005667069 title "The effects of cyclooxygenase-2 gene silencing by siRNA on cell proliferation, cell apoptosis, cell cycle and tumorigenicity of Capan-2 human pancreatic cancer cells" @default.
• W2005667069 cites W2017816682 @default.
• W2005667069 cites W2018982924 @default.
• W2005667069 cites W2060979922 @default.
• W2005667069 cites W2069228549 @default.
• W2005667069 cites W2072705488 @default.
• W2005667069 cites W2073738021 @default.
• W2005667069 cites W2116150988 @default.
• W2005667069 cites W2127607312 @default.
• W2005667069 cites W2158131645 @default.
• W2005667069 cites W2167798587 @default.
• W2005667069 doi "https://doi.org/10.3892/or.2011.1595" @default.
• W2005667069 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3583541" @default.
• W2005667069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22200969" @default.
• W2005667069 hasPublicationYear "2011" @default.
• W2005667069 type Work @default.
• W2005667069 sameAs 2005667069 @default.
• W2005667069 citedByCount "10" @default.
• W2005667069 countsByYear W20056670692012 @default.
• W2005667069 countsByYear W20056670692013 @default.
• W2005667069 countsByYear W20056670692014 @default.
• W2005667069 countsByYear W20056670692015 @default.
• W2005667069 countsByYear W20056670692018 @default.
• W2005667069 countsByYear W20056670692019 @default.
• W2005667069 countsByYear W20056670692021 @default.
• W2005667069 countsByYear W20056670692022 @default.
• W2005667069 crossrefType "journal-article" @default.
• W2005667069 hasAuthorship W2005667069A5009655674 @default.
• W2005667069 hasAuthorship W2005667069A5015722840 @default.
• W2005667069 hasAuthorship W2005667069A5065316840 @default.
• W2005667069 hasAuthorship W2005667069A5080125836 @default.
• W2005667069 hasAuthorship W2005667069A5089812784 @default.
• W2005667069 hasBestOaLocation W20056670691 @default.
• W2005667069 hasConcept C104317684 @default.
• W2005667069 hasConcept C119056186 @default.
• W2005667069 hasConcept C121608353 @default.
• W2005667069 hasConcept C1491633281 @default.
• W2005667069 hasConcept C153911025 @default.
• W2005667069 hasConcept C190283241 @default.
• W2005667069 hasConcept C22615655 @default.
• W2005667069 hasConcept C2780210213 @default.
• W2005667069 hasConcept C2781018059 @default.
• W2005667069 hasConcept C29537977 @default.
• W2005667069 hasConcept C502942594 @default.
• W2005667069 hasConcept C54009773 @default.
• W2005667069 hasConcept C54355233 @default.
• W2005667069 hasConcept C55493867 @default.
• W2005667069 hasConcept C555283112 @default.
• W2005667069 hasConcept C62112901 @default.
• W2005667069 hasConcept C81885089 @default.
• W2005667069 hasConcept C86803240 @default.
• W2005667069 hasConcept C96232424 @default.
• W2005667069 hasConceptScore W2005667069C104317684 @default.
• W2005667069 hasConceptScore W2005667069C119056186 @default.
• W2005667069 hasConceptScore W2005667069C121608353 @default.
• W2005667069 hasConceptScore W2005667069C1491633281 @default.
• W2005667069 hasConceptScore W2005667069C153911025 @default.
• W2005667069 hasConceptScore W2005667069C190283241 @default.
• W2005667069 hasConceptScore W2005667069C22615655 @default.
• W2005667069 hasConceptScore W2005667069C2780210213 @default.
• W2005667069 hasConceptScore W2005667069C2781018059 @default.
• W2005667069 hasConceptScore W2005667069C29537977 @default.
• W2005667069 hasConceptScore W2005667069C502942594 @default.
• W2005667069 hasConceptScore W2005667069C54009773 @default.
• W2005667069 hasConceptScore W2005667069C54355233 @default.
• W2005667069 hasConceptScore W2005667069C55493867 @default.
• W2005667069 hasConceptScore W2005667069C555283112 @default.
• W2005667069 hasConceptScore W2005667069C62112901 @default.
• W2005667069 hasConceptScore W2005667069C81885089 @default.
• W2005667069 hasConceptScore W2005667069C86803240 @default.
• W2005667069 hasConceptScore W2005667069C96232424 @default.
• W2005667069 hasIssue "4" @default.
• W2005667069 hasLocation W20056670691 @default.
• W2005667069 hasLocation W20056670692 @default.
• W2005667069 hasLocation W20056670693 @default.
• W2005667069 hasLocation W20056670694 @default.
• W2005667069 hasOpenAccess W2005667069 @default.
• W2005667069 hasPrimaryLocation W20056670691 @default.
• W2005667069 hasRelatedWork W1956085363 @default.
• W2005667069 hasRelatedWork W2001686617 @default.
• W2005667069 hasRelatedWork W2117441185 @default.
• W2005667069 hasRelatedWork W2348417465 @default.
• W2005667069 hasRelatedWork W2764038087 @default.
• W2005667069 hasRelatedWork W2791208306 @default.
• W2005667069 hasRelatedWork W2808352915 @default.
• W2005667069 hasRelatedWork W2913448208 @default.
• W2005667069 hasRelatedWork W3022642502 @default.
• W2005667069 hasRelatedWork W3045868324 @default.
• W2005667069 hasVolume "27" @default.

• next