Matches in SemOpenAlex for { <https://semopenalex.org/work/W200567166> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W200567166 endingPage "924" @default.
- W200567166 startingPage "921" @default.
- W200567166 abstract "The benefits of fungal prophylaxis with fluconazole in BMT patients appear to outweigh the risks of a possible increase in colonization and infection by C. krusei or T. glabrata. Disseminated fungal infections caused by C. tropicalis and C. albicans have a 38.8% mortality rate, and these infections may be prevented by the prophylactic use of fluconazole. C. krusei and T. glabrata infections generally do not contribute to increased mortality, and most patients infected by these organisms recover after appropriate antifungal therapy. The use of amphotericin B as prophylaxis may have some efficacy. One retrospective study found low-dose amphotericin B therapy to be effective in preventing Candida infections, but results from a placebo-controlled, randomized prospective trial with 0.1 mg/kg/d failed to support this claim. Low-dose amphotericin B prophylaxis (0.1-0.25 mg/kg/d) shows promise against aspergillosis, an opportunistic infection associated with high morbidity and mortality. The literature suggests the possible value of using oral or intravenous fluconazole 200-400 mg/d or intravenous amphotericin B 0.1-0.25 mg/kg/d as antifungal prophylaxis in patients after autologous or allogeneic BMT. Many questions remain unanswered, however. These studies described the potential decrease in morbidity and mortality of BMT patients with the use of either fluconazole or amphotericin B, but it is not known whether all patients after BMT or only those at high risk of fungal infection may benefit from prophylaxis. Optimal dosing of either antifungal agent has not been defined in the studies. Clinicians should be aware of the possible increase in colonization by less pathogenic fungal species, such as C. krusel and T. glabrata, when prescribing fluconazole prophylaxis.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W200567166 created "2016-06-24" @default.
- W200567166 creator A5010937097 @default.
- W200567166 creator A5012023772 @default.
- W200567166 date "1995-09-01" @default.
- W200567166 modified "2023-10-18" @default.
- W200567166 title "Antifungal Prophylaxis in Bone Marrow Transplant" @default.
- W200567166 cites W1908814744 @default.
- W200567166 cites W1973786578 @default.
- W200567166 cites W1979180336 @default.
- W200567166 cites W1985855412 @default.
- W200567166 cites W2010098496 @default.
- W200567166 cites W2039203847 @default.
- W200567166 cites W2106562479 @default.
- W200567166 cites W2135672254 @default.
- W200567166 cites W2339375844 @default.
- W200567166 cites W2341266869 @default.
- W200567166 doi "https://doi.org/10.1177/106002809502900915" @default.
- W200567166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8547742" @default.
- W200567166 hasPublicationYear "1995" @default.
- W200567166 type Work @default.
- W200567166 sameAs 200567166 @default.
- W200567166 citedByCount "12" @default.
- W200567166 crossrefType "journal-article" @default.
- W200567166 hasAuthorship W200567166A5010937097 @default.
- W200567166 hasAuthorship W200567166A5012023772 @default.
- W200567166 hasConcept C126322002 @default.
- W200567166 hasConcept C141071460 @default.
- W200567166 hasConcept C16005928 @default.
- W200567166 hasConcept C177713679 @default.
- W200567166 hasConcept C2776688490 @default.
- W200567166 hasConcept C2779548794 @default.
- W200567166 hasConcept C2779629538 @default.
- W200567166 hasConcept C2780651595 @default.
- W200567166 hasConcept C2780670043 @default.
- W200567166 hasConcept C2780908437 @default.
- W200567166 hasConcept C2781425774 @default.
- W200567166 hasConcept C71924100 @default.
- W200567166 hasConcept C90924648 @default.
- W200567166 hasConceptScore W200567166C126322002 @default.
- W200567166 hasConceptScore W200567166C141071460 @default.
- W200567166 hasConceptScore W200567166C16005928 @default.
- W200567166 hasConceptScore W200567166C177713679 @default.
- W200567166 hasConceptScore W200567166C2776688490 @default.
- W200567166 hasConceptScore W200567166C2779548794 @default.
- W200567166 hasConceptScore W200567166C2779629538 @default.
- W200567166 hasConceptScore W200567166C2780651595 @default.
- W200567166 hasConceptScore W200567166C2780670043 @default.
- W200567166 hasConceptScore W200567166C2780908437 @default.
- W200567166 hasConceptScore W200567166C2781425774 @default.
- W200567166 hasConceptScore W200567166C71924100 @default.
- W200567166 hasConceptScore W200567166C90924648 @default.
- W200567166 hasIssue "9" @default.
- W200567166 hasLocation W2005671661 @default.
- W200567166 hasLocation W2005671662 @default.
- W200567166 hasOpenAccess W200567166 @default.
- W200567166 hasPrimaryLocation W2005671661 @default.
- W200567166 hasRelatedWork W1969010760 @default.
- W200567166 hasRelatedWork W1993022796 @default.
- W200567166 hasRelatedWork W200567166 @default.
- W200567166 hasRelatedWork W2008481260 @default.
- W200567166 hasRelatedWork W2072191297 @default.
- W200567166 hasRelatedWork W2081928829 @default.
- W200567166 hasRelatedWork W2129688861 @default.
- W200567166 hasRelatedWork W2167325229 @default.
- W200567166 hasRelatedWork W2409339893 @default.
- W200567166 hasRelatedWork W2186629012 @default.
- W200567166 hasVolume "29" @default.
- W200567166 isParatext "false" @default.
- W200567166 isRetracted "false" @default.
- W200567166 magId "200567166" @default.
- W200567166 workType "article" @default.