FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005672571> ?p ?o ?g. }

• W2005672571 endingPage "1352" @default.
• W2005672571 startingPage "1340" @default.
• W2005672571 abstract "Inhibitor of differentiation-1 (Id-1) has been shown to play an essential role in cell proliferation, invasion, migration, and anti-apoptosis. However, the effect of Id-1 in mammary gland development remains unknown. Here, we generated MMTV-Id-1 transgenic mice to study the role of Id-1 in mammary gland development. In virgin mice, Id-1 overexpression led to precocious development and delayed regression of terminal end buds (TEBs) compared with wild-type mice. The number of BrdU-positive cells and the expression of Wnt signaling molecules, β-catenin and cyclin D1, which regulate ductal extension and TEB formation in virgin, were statistically higher in Id-1 transgenic mice than in wild-type mice. Id-1 also had an effect on the formation and proliferation of lobuloalveolar structures during early and mid-pregnancy. Id-1 transgenic mice had more lobulated and prominent alveolar budding than wild-type mice and had significantly greater counts of lobuloalveolar structures in early pregnancy. The expression of BrdU, β-catenin, and cyclin D1 was also predominantly increased in Id-1 transgenic mice. Moreover, Id-1 transgenic mice showed delayed involution. Id-1 regulated the expression levels of anti-apoptotic Bcl-2 and pro-apoptotic Bax, and resulted in delay of apoptotic peak during postlactational involution. We also found that Id-1 was able to modulate expression of the regulators of Wnt/β-catenin signaling such as phospho-Akt, BMP2, FGF3, and RAR-β in tubuloalveolar development of mammary glands. Taken together, our results suggest that Id-1 plays a pivotal role in mammary gland development through Wnt signaling-mediated acceleration of precocity and alveologenesis and Bcl-2 family members-mediated delay of involution." @default.
• W2005672571 created "2016-06-24" @default.
• W2005672571 creator A5001681907 @default.
• W2005672571 creator A5024404013 @default.
• W2005672571 creator A5040136102 @default.
• W2005672571 creator A5063477154 @default.
• W2005672571 creator A5072990837 @default.
• W2005672571 creator A5086602832 @default.
• W2005672571 date "2011-02-22" @default.
• W2005672571 modified "2023-10-18" @default.
• W2005672571 title "Constitutive overexpression of Id-1 in mammary glands of transgenic mice results in precocious and increased formation of terminal end buds, enhanced alveologenesis, delayed involution" @default.
• W2005672571 cites W1505072532 @default.
• W2005672571 cites W1520332974 @default.
• W2005672571 cites W1520723027 @default.
• W2005672571 cites W1601214065 @default.
• W2005672571 cites W1929529978 @default.
• W2005672571 cites W1966943171 @default.
• W2005672571 cites W1973140591 @default.
• W2005672571 cites W1990768206 @default.
• W2005672571 cites W1991227171 @default.
• W2005672571 cites W1995563847 @default.
• W2005672571 cites W1997851570 @default.
• W2005672571 cites W2018631055 @default.
• W2005672571 cites W2019705131 @default.
• W2005672571 cites W2035252744 @default.
• W2005672571 cites W2040919885 @default.
• W2005672571 cites W2044261540 @default.
• W2005672571 cites W2049022684 @default.
• W2005672571 cites W2051192665 @default.
• W2005672571 cites W2054374001 @default.
• W2005672571 cites W2057216898 @default.
• W2005672571 cites W2078502999 @default.
• W2005672571 cites W2081673344 @default.
• W2005672571 cites W2085510615 @default.
• W2005672571 cites W2090863421 @default.
• W2005672571 cites W2094411299 @default.
• W2005672571 cites W2096129596 @default.
• W2005672571 cites W2096637314 @default.
• W2005672571 cites W2106454275 @default.
• W2005672571 cites W2109129376 @default.
• W2005672571 cites W2112659798 @default.
• W2005672571 cites W2124883945 @default.
• W2005672571 cites W2136871331 @default.
• W2005672571 cites W2137236648 @default.
• W2005672571 cites W2157189284 @default.
• W2005672571 cites W2159511823 @default.
• W2005672571 cites W2161743675 @default.
• W2005672571 cites W2162802160 @default.
• W2005672571 cites W2163505622 @default.
• W2005672571 cites W2167039798 @default.
• W2005672571 cites W2168018404 @default.
• W2005672571 cites W2316742206 @default.
• W2005672571 cites W2388163742 @default.
• W2005672571 cites W4244341972 @default.
• W2005672571 doi "https://doi.org/10.1002/jcp.22462" @default.
• W2005672571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20945346" @default.
• W2005672571 hasPublicationYear "2011" @default.
• W2005672571 type Work @default.
• W2005672571 sameAs 2005672571 @default.
• W2005672571 citedByCount "8" @default.
• W2005672571 countsByYear W20056725712013 @default.
• W2005672571 countsByYear W20056725712014 @default.
• W2005672571 countsByYear W20056725712015 @default.
• W2005672571 countsByYear W20056725712022 @default.
• W2005672571 countsByYear W20056725712023 @default.
• W2005672571 crossrefType "journal-article" @default.
• W2005672571 hasAuthorship W2005672571A5001681907 @default.
• W2005672571 hasAuthorship W2005672571A5024404013 @default.
• W2005672571 hasAuthorship W2005672571A5040136102 @default.
• W2005672571 hasAuthorship W2005672571A5063477154 @default.
• W2005672571 hasAuthorship W2005672571A5072990837 @default.
• W2005672571 hasAuthorship W2005672571A5086602832 @default.
• W2005672571 hasConcept C102230213 @default.
• W2005672571 hasConcept C104317684 @default.
• W2005672571 hasConcept C120504264 @default.
• W2005672571 hasConcept C121608353 @default.
• W2005672571 hasConcept C126322002 @default.
• W2005672571 hasConcept C134018914 @default.
• W2005672571 hasConcept C137620995 @default.
• W2005672571 hasConcept C141035611 @default.
• W2005672571 hasConcept C169760540 @default.
• W2005672571 hasConcept C186720457 @default.
• W2005672571 hasConcept C190283241 @default.
• W2005672571 hasConcept C199835354 @default.
• W2005672571 hasConcept C2778001805 @default.
• W2005672571 hasConcept C2778437423 @default.
• W2005672571 hasConcept C2781409172 @default.
• W2005672571 hasConcept C29537977 @default.
• W2005672571 hasConcept C30145163 @default.
• W2005672571 hasConcept C502942594 @default.
• W2005672571 hasConcept C530470458 @default.
• W2005672571 hasConcept C54355233 @default.
• W2005672571 hasConcept C62478195 @default.
• W2005672571 hasConcept C71924100 @default.
• W2005672571 hasConcept C86803240 @default.
• W2005672571 hasConcept C95444343 @default.
• W2005672571 hasConceptScore W2005672571C102230213 @default.
• W2005672571 hasConceptScore W2005672571C104317684 @default.

• next