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- W2005672836 abstract "The in vivo effects of convulsant drugs (penicillamine, semicarbazide and isonicotinic acid hydrazide) on the γ-aminobutyric acid (GABA) levels in subcellular fractions were studied in mice. All the drugs reduced the concentration of GABA in the synaptosomal fraction; it was unlikely that this decrease in the GABA concentration was due to redistribution or degradation during the separating procedures. When the convulsions were prevented by simultaneous pyridoxine injection, the GABA level in synaptosomes rose to normal. It is suggested that the decrease of GABA concentration in nerve endings may be an important factor in the onset of some kinds of convulsions." @default.
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- W2005672836 date "1979-09-01" @default.
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- W2005672836 title "γ-Aminobutyric acid in subcellular fractions of mouse brain and its relation to convulsions" @default.
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- W2005672836 doi "https://doi.org/10.1016/0006-2952(79)90563-x" @default.
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