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- W2005673008 abstract "Ca(v)2.1 Ca(2+) channels (P/Q-type), which participate in various key roles in the CNS by mediating calcium influx, are extensively spliced. One of its alternatively-spliced exons is 37, which forms part of the EF hand. The expression of exon 37a (EFa form), but not exon 37b (EFb form), confers the channel an activity-dependent enhancement of channel opening known as Ca(2+)-dependent facilitation (CDF). In this study, we analyzed the trend of EF hand splice variant distributions in mouse, rat and human brain tissues. We observed a developmental switch in rodents, as well as an age and gender bias in human brain tissues, suggestive of a possible role of these EF hand splice variants in neurophysiological specialization. A parallel study performed on rodent brains showed that the data drawn from human and rodent tissues may not necessarily correlate in the process of aging." @default.
- W2005673008 created "2016-06-24" @default.
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- W2005673008 date "2007-03-01" @default.
- W2005673008 modified "2023-10-06" @default.
- W2005673008 title "Age and gender-dependent alternative splicing of P/Q-type calcium channel EF-hand" @default.
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- W2005673008 doi "https://doi.org/10.1016/j.neuroscience.2006.12.054" @default.
- W2005673008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1978091" @default.
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