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- W2005673089 abstract "DHX-9, a member of the DEXH family of RNA helicases, unwinds dsRNA/dsDNA by ATP or GTP-dependent hydrolysis. We asked whether DHX-9 played a role in the GTP depletion-induced inhibition of rRNA synthesis and/or nucleolar disruption. MPA, a specific inhibitor of inosine monophosphate dehydrogenase (IMPDH), induced a rapid translocation of DHX-9 from the nucleolus to the nucleus. EGFP-tagged DHX-9 mutated at the GTP binding site also localized to the nucleus. However, knockdown of DHX-9 by siRNA did not inhibit the rRNA synthesis or cause the nucleolar disruption. Thus, DHX-9 translocation found with IMPDH inhibition does not mediate the inhibition of rRNA synthesis." @default.
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- W2005673089 date "2008-07-23" @default.
- W2005673089 modified "2023-09-26" @default.
- W2005673089 title "Guanine Nucleotide Depletion Mediates Translocation of Nucleolar Proteins, Including RNA Helicase A (DHX-9)" @default.
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- W2005673089 doi "https://doi.org/10.1080/15257770802145132" @default.
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