FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005676888> ?p ?o ?g. }

• W2005676888 endingPage "1086" @default.
• W2005676888 startingPage "1079" @default.
• W2005676888 abstract "Histiotrophic nutrition is essential during the peri-implantation development in rodents, but little is known about receptors involved in protein and lipid endocytosis derived from the endometrium and the uterine glands. Previous studies suggested that cubilin, a multiligand receptor for vitamin, iron, and protein uptake in the adult, might be important in this process, but the onset of its expression and function is not known. In this study, we analyzed the expression of cubilin in the pre- and early post-implantation rodent embryo and tested its potential function in protein and cholesterol uptake. Using morphological and Western blot analysis, we showed that cubilin first appeared at the eight-cell stage. It was expressed by the maternal-fetal interfaces, trophectoderm and visceral endoderm, but also by the future neuroepithelial cells and the developing neural tube. At all these sites, cubilin was localized at the apical pole of the cells exposed to the maternal environment or to the amniotic and neural tube cavities, and had a very similar distribution to megalin, a member of the LDLR gene family and a coreceptor for cubilin in adult tissues. To analyze cubilin function, we followed endocytosis of apolipoprotein A-I and HDL cholesterol, nutrients normally present in the uterine glands and essential for embryonic growth. We showed that internalization of both ligands was cubilin dependent during the early rodent gestation. In conclusion, the early cubilin expression and its function in protein and cholesterol uptake suggest an important role for cubilin in the development of the peri-implantation embryo." @default.
• W2005676888 created "2016-06-24" @default.
• W2005676888 creator A5005170797 @default.
• W2005676888 creator A5011230739 @default.
• W2005676888 creator A5035557210 @default.
• W2005676888 creator A5041771528 @default.
• W2005676888 creator A5048044884 @default.
• W2005676888 creator A5049110914 @default.
• W2005676888 creator A5066913101 @default.
• W2005676888 creator A5078394874 @default.
• W2005676888 creator A5081407836 @default.
• W2005676888 creator A5091573573 @default.
• W2005676888 date "2005-05-01" @default.
• W2005676888 modified "2023-10-07" @default.
• W2005676888 title "Expression and Role of Cubilin in the Internalization of Nutrients During the Peri-Implantation Development of the Rodent Embryo1" @default.
• W2005676888 cites W1488216908 @default.
• W2005676888 cites W1523684025 @default.
• W2005676888 cites W1569219037 @default.
• W2005676888 cites W1651705360 @default.
• W2005676888 cites W1828530273 @default.
• W2005676888 cites W1832775345 @default.
• W2005676888 cites W1921739958 @default.
• W2005676888 cites W1971071799 @default.
• W2005676888 cites W1986909201 @default.
• W2005676888 cites W1989560974 @default.
• W2005676888 cites W1990538137 @default.
• W2005676888 cites W1997529430 @default.
• W2005676888 cites W1999504956 @default.
• W2005676888 cites W2003088795 @default.
• W2005676888 cites W2007909080 @default.
• W2005676888 cites W2015010151 @default.
• W2005676888 cites W2016030121 @default.
• W2005676888 cites W2018122591 @default.
• W2005676888 cites W2036664585 @default.
• W2005676888 cites W2044350559 @default.
• W2005676888 cites W2067839271 @default.
• W2005676888 cites W2086063762 @default.
• W2005676888 cites W2110869010 @default.
• W2005676888 cites W2123715306 @default.
• W2005676888 cites W2130937074 @default.
• W2005676888 cites W2133047224 @default.
• W2005676888 cites W2139149117 @default.
• W2005676888 cites W2158090936 @default.
• W2005676888 cites W2164404896 @default.
• W2005676888 cites W2186296775 @default.
• W2005676888 cites W2298830709 @default.
• W2005676888 cites W2327547063 @default.
• W2005676888 cites W2402787803 @default.
• W2005676888 doi "https://doi.org/10.1095/biolreprod.104.036913" @default.
• W2005676888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15616221" @default.
• W2005676888 hasPublicationYear "2005" @default.
• W2005676888 type Work @default.
• W2005676888 sameAs 2005676888 @default.
• W2005676888 citedByCount "46" @default.
• W2005676888 countsByYear W20056768882012 @default.
• W2005676888 countsByYear W20056768882013 @default.
• W2005676888 countsByYear W20056768882014 @default.
• W2005676888 countsByYear W20056768882015 @default.
• W2005676888 countsByYear W20056768882016 @default.
• W2005676888 countsByYear W20056768882018 @default.
• W2005676888 countsByYear W20056768882019 @default.
• W2005676888 countsByYear W20056768882020 @default.
• W2005676888 countsByYear W20056768882021 @default.
• W2005676888 countsByYear W20056768882022 @default.
• W2005676888 countsByYear W20056768882023 @default.
• W2005676888 crossrefType "journal-article" @default.
• W2005676888 hasAuthorship W2005676888A5005170797 @default.
• W2005676888 hasAuthorship W2005676888A5011230739 @default.
• W2005676888 hasAuthorship W2005676888A5035557210 @default.
• W2005676888 hasAuthorship W2005676888A5041771528 @default.
• W2005676888 hasAuthorship W2005676888A5048044884 @default.
• W2005676888 hasAuthorship W2005676888A5049110914 @default.
• W2005676888 hasAuthorship W2005676888A5066913101 @default.
• W2005676888 hasAuthorship W2005676888A5078394874 @default.
• W2005676888 hasAuthorship W2005676888A5081407836 @default.
• W2005676888 hasAuthorship W2005676888A5091573573 @default.
• W2005676888 hasBestOaLocation W20056768881 @default.
• W2005676888 hasConcept C126322002 @default.
• W2005676888 hasConcept C134018914 @default.
• W2005676888 hasConcept C139770010 @default.
• W2005676888 hasConcept C170493617 @default.
• W2005676888 hasConcept C196843134 @default.
• W2005676888 hasConcept C2780594696 @default.
• W2005676888 hasConcept C28005876 @default.
• W2005676888 hasConcept C55493867 @default.
• W2005676888 hasConcept C71924100 @default.
• W2005676888 hasConcept C86803240 @default.
• W2005676888 hasConcept C87073359 @default.
• W2005676888 hasConcept C95444343 @default.
• W2005676888 hasConceptScore W2005676888C126322002 @default.
• W2005676888 hasConceptScore W2005676888C134018914 @default.
• W2005676888 hasConceptScore W2005676888C139770010 @default.
• W2005676888 hasConceptScore W2005676888C170493617 @default.
• W2005676888 hasConceptScore W2005676888C196843134 @default.
• W2005676888 hasConceptScore W2005676888C2780594696 @default.
• W2005676888 hasConceptScore W2005676888C28005876 @default.
• W2005676888 hasConceptScore W2005676888C55493867 @default.
• W2005676888 hasConceptScore W2005676888C71924100 @default.

• next