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• W2005679096 abstract "Surprisingly, although highly temperature-sensitive, thebimA1 APC3 anaphase-promoting complex/cyclosome (APC/C) mutation does not cause arrest of mitotic exit. Instead, rapid inactivation ofbimA1 APC3 is shown to promote repeating oscillations of chromosome condensation and decondensation, activation and inactivation of NIMA and p34 cdc2 kinases, and accumulation and degradation of NIMA, which all coordinately cycle multiple times without causing nuclear division. ThesebimA1 APC3 -induced cell cycle oscillations require active NIMA, because a nimA5 +bimA1 APC3 double mutant arrests in a mitotic state with very high p34 cdc2 H1 kinase activity. NIMA protein instability during S phase and G2 was also found to be controlled by the APC/C. The bimA1 APC3 mutation therefore first inactivates the APC/C but then allows its activation in a cyclic manner; these cycles depend on NIMA. We hypothesize that bimA APC3 could be part of a cell cycle clock mechanism that is reset after inactivation ofbimA1 APC3 . ThebimA1 APC3 mutation may also make the APC/C resistant to activation by mitotic substrates of the APC/C, such as cyclin B, Polo, and NIMA, causing mitotic delay. Once these regulators accumulate, they activate the APC/C, and cells exit from mitosis, which then allows this cycle to repeat. The data indicate thatbimA APC3 regulates the APC/C in a NIMA-dependent manner." @default.
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• W2005679096 date "1998-11-01" @default.
• W2005679096 modified "2023-09-25" @default.
• W2005679096 title "Regulation of the Anaphase-promoting Complex/Cyclosome by<i>bimA</i>^APC3and Proteolysis of NIMA" @default.
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• W2005679096 doi "https://doi.org/10.1091/mbc.9.11.3019" @default.
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