FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005682259> ?p ?o ?g. }

• W2005682259 endingPage "413" @default.
• W2005682259 startingPage "400" @default.
• W2005682259 abstract "Among the proteins whose synthesis and/or degradation is necessary for a proper progression through meiotic maturation, cyclin B appears to be one of the most important. Here, we attempted to modulate the level of cyclin B1 and B2 synthesis during meiotic maturation of the mouse oocyte. We used cyclin B1 or B2 mRNAs with poly(A) tails of different sizes and cyclin B1 or B2 antisense RNAs. Oocytes microinjected with cyclin B1 mRNA showed two phenotypes: most were blocked in MI, while the others extruded the first polar body in advance when compared to controls. Moreover, these effects were correlated with the length of the poly(A) tail. Thus it seems that the rate of cyclin B1 translation controls the timing of the first meiotic M phase and the transition to anaphase I. Moreover, overexpression of cyclin B1 or B2 was able to bypass the dbcAMP-induced germinal vesicle block, but only the cyclin B1 mRNA-microinjected oocytes did not extrude their first polar body. Oocytes injected with the cyclin B1 antisense progressed through the first meiotic M phase but extruded the first polar body in advance and were unable to enter metaphase II. This suggested that inhibition of cyclin B1 synthesis only took place at the end of the first meiotic M phase, most likely because the cyclin B1 mRNA was protected. The injection of cyclin B2 antisense RNA had no effect. The life observation of the synthesis and degradation of a cyclin B1-GFP chimera during meiotic maturation of the mouse oocyte demonstrated that degradation can only occur during a given period of time once it has started. Taken together, our data demonstrate that the rates of cyclin B synthesis and degradation determine the timing of the major events taking place during meiotic maturation of the mouse oocyte." @default.
• W2005682259 created "2016-06-24" @default.
• W2005682259 creator A5014789415 @default.
• W2005682259 creator A5036857513 @default.
• W2005682259 creator A5054027067 @default.
• W2005682259 creator A5068012613 @default.
• W2005682259 date "2001-04-01" @default.
• W2005682259 modified "2023-09-30" @default.
• W2005682259 title "Meiotic Maturation of the Mouse Oocyte Requires an Equilibrium between Cyclin B Synthesis and Degradation" @default.
• W2005682259 cites W126837237 @default.
• W2005682259 cites W129634405 @default.
• W2005682259 cites W1483395792 @default.
• W2005682259 cites W1542081345 @default.
• W2005682259 cites W1551252363 @default.
• W2005682259 cites W1683365913 @default.
• W2005682259 cites W173481923 @default.
• W2005682259 cites W1823115095 @default.
• W2005682259 cites W1899280238 @default.
• W2005682259 cites W1974679382 @default.
• W2005682259 cites W1981772689 @default.
• W2005682259 cites W1986148855 @default.
• W2005682259 cites W1991101546 @default.
• W2005682259 cites W1991126271 @default.
• W2005682259 cites W1993995783 @default.
• W2005682259 cites W1995796393 @default.
• W2005682259 cites W1999765420 @default.
• W2005682259 cites W2003215039 @default.
• W2005682259 cites W2011802485 @default.
• W2005682259 cites W2014484676 @default.
• W2005682259 cites W2031576542 @default.
• W2005682259 cites W2038948621 @default.
• W2005682259 cites W2047799300 @default.
• W2005682259 cites W2048990794 @default.
• W2005682259 cites W2052162735 @default.
• W2005682259 cites W2057811505 @default.
• W2005682259 cites W2059568263 @default.
• W2005682259 cites W2077312907 @default.
• W2005682259 cites W2087465471 @default.
• W2005682259 cites W2090827556 @default.
• W2005682259 cites W2092805876 @default.
• W2005682259 cites W2093668723 @default.
• W2005682259 cites W2094639271 @default.
• W2005682259 cites W2096733041 @default.
• W2005682259 cites W2100837269 @default.
• W2005682259 cites W2101497044 @default.
• W2005682259 cites W2107423274 @default.
• W2005682259 cites W2111760870 @default.
• W2005682259 cites W2120863005 @default.
• W2005682259 cites W2133128874 @default.
• W2005682259 cites W2145913988 @default.
• W2005682259 cites W2147220557 @default.
• W2005682259 cites W2187720378 @default.
• W2005682259 cites W2217663772 @default.
• W2005682259 cites W2324660863 @default.
• W2005682259 cites W2345621860 @default.
• W2005682259 cites W2363811909 @default.
• W2005682259 cites W2409840287 @default.
• W2005682259 cites W253208710 @default.
• W2005682259 cites W329372167 @default.
• W2005682259 doi "https://doi.org/10.1006/dbio.2001.0188" @default.
• W2005682259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11401401" @default.
• W2005682259 hasPublicationYear "2001" @default.
• W2005682259 type Work @default.
• W2005682259 sameAs 2005682259 @default.
• W2005682259 citedByCount "168" @default.
• W2005682259 countsByYear W20056822592012 @default.
• W2005682259 countsByYear W20056822592013 @default.
• W2005682259 countsByYear W20056822592014 @default.
• W2005682259 countsByYear W20056822592015 @default.
• W2005682259 countsByYear W20056822592016 @default.
• W2005682259 countsByYear W20056822592017 @default.
• W2005682259 countsByYear W20056822592018 @default.
• W2005682259 countsByYear W20056822592019 @default.
• W2005682259 countsByYear W20056822592020 @default.
• W2005682259 countsByYear W20056822592021 @default.
• W2005682259 countsByYear W20056822592022 @default.
• W2005682259 countsByYear W20056822592023 @default.
• W2005682259 crossrefType "journal-article" @default.
• W2005682259 hasAuthorship W2005682259A5014789415 @default.
• W2005682259 hasAuthorship W2005682259A5036857513 @default.
• W2005682259 hasAuthorship W2005682259A5054027067 @default.
• W2005682259 hasAuthorship W2005682259A5068012613 @default.
• W2005682259 hasBestOaLocation W20056822591 @default.
• W2005682259 hasConcept C11882975 @default.
• W2005682259 hasConcept C120089663 @default.
• W2005682259 hasConcept C120504264 @default.
• W2005682259 hasConcept C153911025 @default.
• W2005682259 hasConcept C16438837 @default.
• W2005682259 hasConcept C190283241 @default.
• W2005682259 hasConcept C196843134 @default.
• W2005682259 hasConcept C2776690073 @default.
• W2005682259 hasConcept C2778437423 @default.
• W2005682259 hasConcept C28179978 @default.
• W2005682259 hasConcept C29537977 @default.
• W2005682259 hasConcept C2994119143 @default.
• W2005682259 hasConcept C54355233 @default.
• W2005682259 hasConcept C86803240 @default.
• W2005682259 hasConcept C94561458 @default.

• next