FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005686750> ?p ?o ?g. }

• W2005686750 endingPage "234" @default.
• W2005686750 startingPage "225" @default.
• W2005686750 abstract "Protease-sensitive macromolecular prodrugs have attracted interest for bio-responsive drug delivery to sites with up-regulated proteolytic activities such as inflammatory or cancerous lesions. Here we report the development of a novel polymeric photosensitizer prodrug (T-PS) to target thrombin, a protease up-regulated in synovial tissues of rheumatoid arthritis (RA) patients, for minimally invasive photodynamic synovectomy. In T-PS, multiple photosensitizer units are tethered to a polymeric backbone via short, thrombin-cleavable peptide linkers. Photoactivity of the prodrug is efficiently impaired due to energy transfer between neighbouring photosensitizer units. T-PS activation by exogenous and endogenous thrombin induced an increase in fluorescence emission by a factor of 16 after in vitro digestion and a selective fluorescence enhancement in arthritic lesions in vivo, in a collagen-induced arthritis mouse model. In vitro studies on primary human synoviocytes showed a phototoxic effect only after enzymatic digestion of the prodrug and light irradiation, thus demonstrating the functionality of T-PS induced PDT. The developed photosensitizer prodrugs combine the passive targeting capacity of macromolecular drug delivery systems with site-selective photosensitizer release and activation. They illuminate lesions with pathologically enhanced proteolytic activity and induce cell death, subsequent to irradiation." @default.
• W2005686750 created "2016-06-24" @default.
• W2005686750 creator A5013683035 @default.
• W2005686750 creator A5016349256 @default.
• W2005686750 creator A5033873495 @default.
• W2005686750 creator A5058245369 @default.
• W2005686750 creator A5086992625 @default.
• W2005686750 creator A5087442210 @default.
• W2005686750 date "2009-09-01" @default.
• W2005686750 modified "2023-10-04" @default.
• W2005686750 title "Thrombin-sensitive photodynamic agents: A novel strategy for selective synovectomy in rheumatoid arthritis" @default.
• W2005686750 cites W1596848781 @default.
• W2005686750 cites W1946363155 @default.
• W2005686750 cites W1965490057 @default.
• W2005686750 cites W1969815247 @default.
• W2005686750 cites W1970822699 @default.
• W2005686750 cites W1971430341 @default.
• W2005686750 cites W1978576762 @default.
• W2005686750 cites W1978714754 @default.
• W2005686750 cites W1984417493 @default.
• W2005686750 cites W1991859734 @default.
• W2005686750 cites W1994120286 @default.
• W2005686750 cites W1998787995 @default.
• W2005686750 cites W2005246753 @default.
• W2005686750 cites W2006188663 @default.
• W2005686750 cites W2016562136 @default.
• W2005686750 cites W2023548097 @default.
• W2005686750 cites W2026599765 @default.
• W2005686750 cites W2031092466 @default.
• W2005686750 cites W2039968228 @default.
• W2005686750 cites W2044084696 @default.
• W2005686750 cites W2051266917 @default.
• W2005686750 cites W2052753113 @default.
• W2005686750 cites W2071125490 @default.
• W2005686750 cites W2071345412 @default.
• W2005686750 cites W2072873953 @default.
• W2005686750 cites W2077735708 @default.
• W2005686750 cites W2078624814 @default.
• W2005686750 cites W2081561517 @default.
• W2005686750 cites W2083549837 @default.
• W2005686750 cites W2083916193 @default.
• W2005686750 cites W2102859558 @default.
• W2005686750 cites W2105393177 @default.
• W2005686750 cites W2105998191 @default.
• W2005686750 cites W2107610674 @default.
• W2005686750 cites W2111676782 @default.
• W2005686750 cites W2119708791 @default.
• W2005686750 cites W2121844473 @default.
• W2005686750 cites W2121915271 @default.
• W2005686750 cites W2126195044 @default.
• W2005686750 cites W2131578075 @default.
• W2005686750 cites W2136458673 @default.
• W2005686750 cites W2137208120 @default.
• W2005686750 cites W2147516750 @default.
• W2005686750 cites W2160793292 @default.
• W2005686750 cites W2162432485 @default.
• W2005686750 cites W2171274956 @default.
• W2005686750 cites W2405220776 @default.
• W2005686750 doi "https://doi.org/10.1016/j.jconrel.2009.05.012" @default.
• W2005686750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19445983" @default.
• W2005686750 hasPublicationYear "2009" @default.
• W2005686750 type Work @default.
• W2005686750 sameAs 2005686750 @default.
• W2005686750 citedByCount "34" @default.
• W2005686750 countsByYear W20056867502012 @default.
• W2005686750 countsByYear W20056867502013 @default.
• W2005686750 countsByYear W20056867502014 @default.
• W2005686750 countsByYear W20056867502015 @default.
• W2005686750 countsByYear W20056867502016 @default.
• W2005686750 countsByYear W20056867502017 @default.
• W2005686750 countsByYear W20056867502018 @default.
• W2005686750 countsByYear W20056867502019 @default.
• W2005686750 countsByYear W20056867502020 @default.
• W2005686750 countsByYear W20056867502021 @default.
• W2005686750 countsByYear W20056867502022 @default.
• W2005686750 countsByYear W20056867502023 @default.
• W2005686750 crossrefType "journal-article" @default.
• W2005686750 hasAuthorship W2005686750A5013683035 @default.
• W2005686750 hasAuthorship W2005686750A5016349256 @default.
• W2005686750 hasAuthorship W2005686750A5033873495 @default.
• W2005686750 hasAuthorship W2005686750A5058245369 @default.
• W2005686750 hasAuthorship W2005686750A5086992625 @default.
• W2005686750 hasAuthorship W2005686750A5087442210 @default.
• W2005686750 hasConcept C108215921 @default.
• W2005686750 hasConcept C12554922 @default.
• W2005686750 hasConcept C150903083 @default.
• W2005686750 hasConcept C178790620 @default.
• W2005686750 hasConcept C181199279 @default.
• W2005686750 hasConcept C185592680 @default.
• W2005686750 hasConcept C202751555 @default.
• W2005686750 hasConcept C203014093 @default.
• W2005686750 hasConcept C207001950 @default.
• W2005686750 hasConcept C2776714187 @default.
• W2005686750 hasConcept C2777077863 @default.
• W2005686750 hasConcept C2777292125 @default.
• W2005686750 hasConcept C2781323092 @default.
• W2005686750 hasConcept C2781469039 @default.
• W2005686750 hasConcept C502942594 @default.

• next