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• W2005687574 abstract "<b><i>Background:</i></b> Cutaneous pigmented lesions urge the need to find safe and effective treatments to lighten the skin. <b><i>Objective:</i></b> The aim of this study was to combine a retinoid (retinaldehyde), a new phenolic agent (4-(1-phenylethyl)-resorcinol) and a proreducing agent (δ-tocopheryl-β-<smlcap>D</smlcap>-glucopyranoside) to achieve synergistic actions for skin lightening. <b><i>Methods:</i></b> The tolerance profile and the depigmenting properties of these agents were assessed in murine keratinocyte and melanocyte cell lines, as well as in a 3-dimensional model of reconstructed epidermis. <b><i>Results:</i></b> Retinaldehyde and 4-(1-phenylethyl)-resorcinol induced a significant decrease of tissue viability in reconstructed epidermis, but this cytotoxicity was prevented by the addition of δ-tocopheryl-β-<smlcap>D</smlcap>-glucopyranoside. The combination of the three agents was, however, efficient in decreasing the specific melanin content and the density of active melanocytes. <b><i>Conclusion:</i></b> A combination of various chemicals acting via different mechanisms allows a decrease in the toxicity of each compound alone while retaining optimal skin-lightening properties." @default.
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• W2005687574 date "2013-01-01" @default.
• W2005687574 modified "2023-10-17" @default.
• W2005687574 title "The Combination of a Retinoid, a Phenolic Agent and an Antioxidant Improves Tolerance while Retaining an Optimal Depigmenting Action in Reconstructed Epidermis" @default.
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• W2005687574 doi "https://doi.org/10.1159/000353578" @default.
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