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- W2005688313 abstract "Synthetic studies toward the spiroketal core of spirangien A are described. Two synthetic approaches were developed. Both of them use a diastereoselective aldol addition of a lithium enolate derived from a methyl ketone on an aldehyde. In the first approach, the introduction of the (E)-trisubstituted terminal olefin was achieved by using an iron-catalyzed cross-coupling between an alkyl iodide and a vinyl Grignard reagent and a randomly protected spiroketal was obtained. In the second approach, a highly functionalized spiroketal carbamate, which includes 13 stereogenic centers, was successfully isolated." @default.
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- W2005688313 date "2010-07-08" @default.
- W2005688313 modified "2023-10-18" @default.
- W2005688313 title "Synthetic Efforts toward the Spiroketal Core of Spirangien A" @default.
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- W2005688313 doi "https://doi.org/10.1021/jo100871m" @default.
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