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- W2005689887 abstract "Hypersensitivity pneumonitis is an interstitial lung disease mediated through a patient's immunologic response to a variety of inhaled organic dusts. Studies of the cellular components of lavage fluid from patients with this disease show marked increases of CD8+ suppressor/cytotoxic T-lymphocytes.In this study, we identified, in addition to the expected suppressor T-cells and natural killer cells, follicle-like aggregates of B-cells in the lung interstitium of an affected patient.The patient was an 11-year-old non-asthmatic, Caucasian male who presented with a 4-month history of progressive dyspnea, cough, and fever. The home contained nine cockatiel and two doves. Admission pulmonary functions revealed a restrictive pattern with diminished diffusion capacity. Prior to a diagnosis, the patient underwent bronchoalveolar lavage and transbronchial biopsy. Serum precipitins were eventually positive to pigeon (which cross-reacts with dove) droppings. The symptoms resolved after a prolonged course of prednisone.Analysis of bronchoalveolar lavage lymphocyte population revealed a predominance of CD8+ cells (50%) with 85% expressing the activation marker HLA-DR. The percentage of CD4+ and CD56+ were 32% and 16%, respectively. The transbronchial biopsy revealed CD20+ follicle-like aggregates within the lung interstitium.The histopathologic findings confirm that in hypersensitivity pneumonitis, the predominant immune response is an infiltrate of CD8+ T cells. The presence of B cell aggregates, however, may indicate that the local synthesis of antibody may be involved in an antibody-dependent cellular cytotoxic mechanism." @default.
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- W2005689887 date "1999-11-01" @default.
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- W2005689887 title "B-Lymphocyte aggregates in alveoli from a child with hypersensitivity pneumonitis (bird breeders lung)" @default.
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- W2005689887 doi "https://doi.org/10.1016/s1081-1206(10)62831-1" @default.
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