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- W2005690500 abstract "MicroRNAs (miRNAs) are small non-coding RNAs mediating the regulation of gene expression in various biological contexts, including carcinogenesis. Here, we screened putative associations between 34, 45, and 103 miRNAs and 164, 391, and 81 mRNAs via Argonaute1 (Ago1) or Ago2 immunoprecipitation (IP) experiments in a colon cancer cell line. We used a combination of RIP Seq analysis. RNAs that were co-immunoprecipitated with Ago1 or Ago2 were used for massively parallel small RNA and mRNA sequencing. The detected miRNAs and mRNAs were further associated with one another based on in silico target predictions. Analysis of the putative associations indicated that, although Ago1 and Ago2 shared a similar repertory of miRNAs, the mRNAs possibly regulated by those miRNAs seemed different. The mRNAs detected with Ago1 IP were indicated to be frequently associated with genes having constitutive cellular functions, regulated by a smaller number of miRNAs, and appeared to receive more stringent translational regulation. In contrast, putative miRNA-mRNA associations detected with Ago2 IP appeared to be related to signal transduction genes, which had a larger number of possible miRNA binding sites. We then conducted a similar analysis using the colon cancer cells cultured under hypoxia and identified potential hypoxia-induced miRNA-mRNA associations, which included several well-characterized cancer-related genes as novel putative miRNA targets." @default.
- W2005690500 created "2016-06-24" @default.
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- W2005690500 creator A5056627631 @default.
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- W2005690500 date "2014-01-01" @default.
- W2005690500 modified "2023-09-30" @default.
- W2005690500 title "Screening for possible miRNA–mRNA associations in a colon cancer cell line" @default.
- W2005690500 cites W1965854786 @default.
- W2005690500 cites W1967443709 @default.
- W2005690500 cites W1971556742 @default.
- W2005690500 cites W1980269624 @default.
- W2005690500 cites W1981898947 @default.
- W2005690500 cites W1982191152 @default.
- W2005690500 cites W1984409810 @default.
- W2005690500 cites W1985563073 @default.
- W2005690500 cites W1986009297 @default.
- W2005690500 cites W1988105611 @default.
- W2005690500 cites W1988153625 @default.
- W2005690500 cites W1988184140 @default.
- W2005690500 cites W1989773675 @default.
- W2005690500 cites W1989910375 @default.
- W2005690500 cites W1990749424 @default.
- W2005690500 cites W2000712684 @default.
- W2005690500 cites W2005250386 @default.
- W2005690500 cites W2009229545 @default.
- W2005690500 cites W2010890469 @default.
- W2005690500 cites W2012876493 @default.
- W2005690500 cites W2017426710 @default.
- W2005690500 cites W2022083755 @default.
- W2005690500 cites W2026570544 @default.
- W2005690500 cites W2027755252 @default.
- W2005690500 cites W2032945651 @default.
- W2005690500 cites W2033724104 @default.
- W2005690500 cites W2036534625 @default.
- W2005690500 cites W2042911870 @default.
- W2005690500 cites W2047119105 @default.
- W2005690500 cites W2052974657 @default.
- W2005690500 cites W2053758959 @default.
- W2005690500 cites W2054546933 @default.
- W2005690500 cites W2059382687 @default.
- W2005690500 cites W2067961704 @default.
- W2005690500 cites W2070993269 @default.
- W2005690500 cites W2071596792 @default.
- W2005690500 cites W2076984671 @default.
- W2005690500 cites W2082213106 @default.
- W2005690500 cites W2082483448 @default.
- W2005690500 cites W2083381199 @default.
- W2005690500 cites W2085592081 @default.
- W2005690500 cites W2095125813 @default.
- W2005690500 cites W2100369185 @default.
- W2005690500 cites W2101543035 @default.
- W2005690500 cites W2104806799 @default.
- W2005690500 cites W2104985090 @default.
- W2005690500 cites W2114058102 @default.
- W2005690500 cites W2116000203 @default.
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- W2005690500 cites W2121447250 @default.
- W2005690500 cites W2128882718 @default.
- W2005690500 cites W2130701926 @default.
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- W2005690500 cites W2136242764 @default.
- W2005690500 cites W2137334937 @default.
- W2005690500 cites W2144038313 @default.
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- W2005690500 cites W2148008586 @default.
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- W2005690500 doi "https://doi.org/10.1016/j.gene.2013.08.005" @default.
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