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• W2005692204 abstract "Human peroxisome proliferator-activated receptors (hPPARs) are ligand-activated transcription factors and are the target for the treatment of many diseases. Screening of their ligands is mainly based on assays of ligand binding to the ligand binding domain (LBD) of hPPARs.However, such assays are difficult because of the preparation of hPPARs LBD. In order to yield functional hPPARs LBD for screening ligands, hPPARs LBD was fused with maltose-binding protein(MBP) using the pMAL-p2x expression system through the gene engineering technique. The radioligand binding assay showed that MBP did not affect ligand binding with hPPARs LBD in the fusion proteins, which means that MBP-hPPARs LBD can be used instead of hPPARs LBD in ligand screening work. The results show that the new strategy using MBP as a fusion tag for preparing hPPARs LBD for screening ligands is a convenient and reliable method. It may be used to easily obtain the other nuclear receptors." @default.
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• W2005692204 date "2008-12-01" @default.
• W2005692204 modified "2023-09-26" @default.
• W2005692204 title "Expression of Human Peroxisome Proliferator-Activated Receptors Ligand Binding Domain–Maltose Binding Protein Fusion Protein inEscherichia coli:A Convenient and Reliable Method for Preparing Receptor for Screening Ligands" @default.
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• W2005692204 doi "https://doi.org/10.1089/adt.2008.141" @default.
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