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- W2005692904 abstract "Hydrazide derivatives of Ilomastat, carrying either aryl groups or distinct alkyl and arylsulfonyl moieties were synthesized and evaluated for their MMP inhibitory activity. Potent and selective MMP-9 inhibition (IC50 = 3 nM) was observed for compound 3m (arylsulfonyl group: 4-(4-Br–C6H4)–C6H4–SO2–). Interaction with the S2 enzyme subsite is mainly responsible for the inhibitory properties of this derivative as confirmed by molecular docking computation." @default.
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- W2005692904 date "2008-09-01" @default.
- W2005692904 modified "2023-10-16" @default.
- W2005692904 title "Introduction of the 4-(4-bromophenyl)benzenesulfonyl group to hydrazide analogs of Ilomastat leads to potent gelatinase B (MMP-9) inhibitors with improved selectivity" @default.
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- W2005692904 doi "https://doi.org/10.1016/j.bmc.2008.07.041" @default.
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