FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005693939> ?p ?o ?g. }

• W2005693939 endingPage "1154" @default.
• W2005693939 startingPage "1148" @default.
• W2005693939 abstract "Purpose Recent in vitro results have shown significant contributions to cell killing from signaling effects at doses that are typically used in radiation therapy. This study investigates whether these in vitro observations can be reconciled with in vivo knowledge and how signaling may have an impact on future developments in radiation therapy. Methods and Materials Prostate cancer treatment plans were generated for a series of 10 patients using 3-dimensional conformal therapy, intensity modulated radiation therapy (IMRT), and volumetric modulated arc therapy techniques. These plans were evaluated using mathematical models of survival following modulated radiation exposures that were developed from in vitro observations and incorporate the effects of intercellular signaling. The impact on dose–volume histograms and mean doses were evaluated by converting these survival levels into “signaling-adjusted doses” for comparison. Results Inclusion of intercellular communication leads to significant differences between the signalling-adjusted and physical doses across a large volume. Organs in low-dose regions near target volumes see the largest increases, with mean signaling-adjusted bladder doses increasing from 23 to 33 Gy in IMRT plans. By contrast, in high-dose regions, there is a small decrease in signaling-adjusted dose due to reduced contributions from neighboring cells, with planning target volume mean doses falling from 74 to 71 Gy in IMRT. Overall, however, the dose distributions remain broadly similar, and comparisons between the treatment modalities are largely unchanged whether physical or signaling-adjusted dose is compared. Conclusions Although incorporating cellular signaling significantly affects cell killing in low-dose regions and suggests a different interpretation for many phenomena, their effect in high-dose regions for typical planning techniques is comparatively small. This indicates that the significant signaling effects observed in vitro are not contradicted by comparison with clinical observations. Future investigations are needed to validate these effects in vivo and to quantify their ranges and potential impact on more advanced radiation therapy techniques. Recent in vitro results have shown significant contributions to cell killing from signaling effects at doses that are typically used in radiation therapy. This study investigates whether these in vitro observations can be reconciled with in vivo knowledge and how signaling may have an impact on future developments in radiation therapy. Prostate cancer treatment plans were generated for a series of 10 patients using 3-dimensional conformal therapy, intensity modulated radiation therapy (IMRT), and volumetric modulated arc therapy techniques. These plans were evaluated using mathematical models of survival following modulated radiation exposures that were developed from in vitro observations and incorporate the effects of intercellular signaling. The impact on dose–volume histograms and mean doses were evaluated by converting these survival levels into “signaling-adjusted doses” for comparison. Inclusion of intercellular communication leads to significant differences between the signalling-adjusted and physical doses across a large volume. Organs in low-dose regions near target volumes see the largest increases, with mean signaling-adjusted bladder doses increasing from 23 to 33 Gy in IMRT plans. By contrast, in high-dose regions, there is a small decrease in signaling-adjusted dose due to reduced contributions from neighboring cells, with planning target volume mean doses falling from 74 to 71 Gy in IMRT. Overall, however, the dose distributions remain broadly similar, and comparisons between the treatment modalities are largely unchanged whether physical or signaling-adjusted dose is compared. Although incorporating cellular signaling significantly affects cell killing in low-dose regions and suggests a different interpretation for many phenomena, their effect in high-dose regions for typical planning techniques is comparatively small. This indicates that the significant signaling effects observed in vitro are not contradicted by comparison with clinical observations. Future investigations are needed to validate these effects in vivo and to quantify their ranges and potential impact on more advanced radiation therapy techniques." @default.
• W2005693939 created "2016-06-24" @default.
• W2005693939 creator A5014617881 @default.
• W2005693939 creator A5016070046 @default.
• W2005693939 creator A5044156541 @default.
• W2005693939 creator A5048994559 @default.
• W2005693939 creator A5068876364 @default.
• W2005693939 creator A5076875343 @default.
• W2005693939 date "2013-12-01" @default.
• W2005693939 modified "2023-10-17" @default.
• W2005693939 title "Implications of Intercellular Signaling for Radiation Therapy: A Theoretical Dose-Planning Study" @default.
• W2005693939 cites W1973296540 @default.
• W2005693939 cites W1975502046 @default.
• W2005693939 cites W1980983550 @default.
• W2005693939 cites W1983882042 @default.
• W2005693939 cites W1995324520 @default.
• W2005693939 cites W1999494285 @default.
• W2005693939 cites W2003218091 @default.
• W2005693939 cites W2010357749 @default.
• W2005693939 cites W2012514380 @default.
• W2005693939 cites W2014433188 @default.
• W2005693939 cites W2033456044 @default.
• W2005693939 cites W2061611865 @default.
• W2005693939 cites W2063838462 @default.
• W2005693939 cites W2068634088 @default.
• W2005693939 cites W2081852424 @default.
• W2005693939 cites W2104999329 @default.
• W2005693939 cites W2140009560 @default.
• W2005693939 cites W2141983610 @default.
• W2005693939 cites W2153173211 @default.
• W2005693939 cites W2168241051 @default.
• W2005693939 cites W2171465583 @default.
• W2005693939 doi "https://doi.org/10.1016/j.ijrobp.2013.08.021" @default.
• W2005693939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24119835" @default.
• W2005693939 hasPublicationYear "2013" @default.
• W2005693939 type Work @default.
• W2005693939 sameAs 2005693939 @default.
• W2005693939 citedByCount "19" @default.
• W2005693939 countsByYear W20056939392014 @default.
• W2005693939 countsByYear W20056939392015 @default.
• W2005693939 countsByYear W20056939392016 @default.
• W2005693939 countsByYear W20056939392017 @default.
• W2005693939 countsByYear W20056939392018 @default.
• W2005693939 countsByYear W20056939392019 @default.
• W2005693939 crossrefType "journal-article" @default.
• W2005693939 hasAuthorship W2005693939A5014617881 @default.
• W2005693939 hasAuthorship W2005693939A5016070046 @default.
• W2005693939 hasAuthorship W2005693939A5044156541 @default.
• W2005693939 hasAuthorship W2005693939A5048994559 @default.
• W2005693939 hasAuthorship W2005693939A5068876364 @default.
• W2005693939 hasAuthorship W2005693939A5076875343 @default.
• W2005693939 hasConcept C121608353 @default.
• W2005693939 hasConcept C125118446 @default.
• W2005693939 hasConcept C126322002 @default.
• W2005693939 hasConcept C150903083 @default.
• W2005693939 hasConcept C201645570 @default.
• W2005693939 hasConcept C207001950 @default.
• W2005693939 hasConcept C2780192828 @default.
• W2005693939 hasConcept C2989005 @default.
• W2005693939 hasConcept C509974204 @default.
• W2005693939 hasConcept C71924100 @default.
• W2005693939 hasConcept C79879829 @default.
• W2005693939 hasConcept C86803240 @default.
• W2005693939 hasConcept C95444343 @default.
• W2005693939 hasConceptScore W2005693939C121608353 @default.
• W2005693939 hasConceptScore W2005693939C125118446 @default.
• W2005693939 hasConceptScore W2005693939C126322002 @default.
• W2005693939 hasConceptScore W2005693939C150903083 @default.
• W2005693939 hasConceptScore W2005693939C201645570 @default.
• W2005693939 hasConceptScore W2005693939C207001950 @default.
• W2005693939 hasConceptScore W2005693939C2780192828 @default.
• W2005693939 hasConceptScore W2005693939C2989005 @default.
• W2005693939 hasConceptScore W2005693939C509974204 @default.
• W2005693939 hasConceptScore W2005693939C71924100 @default.
• W2005693939 hasConceptScore W2005693939C79879829 @default.
• W2005693939 hasConceptScore W2005693939C86803240 @default.
• W2005693939 hasConceptScore W2005693939C95444343 @default.
• W2005693939 hasIssue "5" @default.
• W2005693939 hasLocation W20056939391 @default.
• W2005693939 hasLocation W20056939392 @default.
• W2005693939 hasOpenAccess W2005693939 @default.
• W2005693939 hasPrimaryLocation W20056939391 @default.
• W2005693939 hasRelatedWork W1972672654 @default.
• W2005693939 hasRelatedWork W1983863207 @default.
• W2005693939 hasRelatedWork W2086631544 @default.
• W2005693939 hasRelatedWork W2098154216 @default.
• W2005693939 hasRelatedWork W2154276734 @default.
• W2005693939 hasRelatedWork W2274455399 @default.
• W2005693939 hasRelatedWork W2788527805 @default.
• W2005693939 hasRelatedWork W3032252569 @default.
• W2005693939 hasRelatedWork W4285491790 @default.
• W2005693939 hasRelatedWork W935391112 @default.
• W2005693939 hasVolume "87" @default.
• W2005693939 isParatext "false" @default.
• W2005693939 isRetracted "false" @default.
• W2005693939 magId "2005693939" @default.
• W2005693939 workType "article" @default.