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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005694530> ?p ?o ?g. }

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• W2005694530 abstract "A study is presented of the proteins of cervical mucus in relation to its changing physical properties. The effects of various low dose progestagens on these characteristics were investigated. A technique was developed to solubilize cervical mucus so that protein quantitation, reproducible disc electrophoresis and immunodiffusion could be carried out. Protein concentration reached a nadir at midcycle. Whe n progestagens of the 17-α-acetoxy series were given the lowest level was significantly higher than at midcycle in normal cycles and when norgestrel 75 μg. was administered at which time only albumin was present. In progestational states the concentration of protein was higher and in addition immunoglobulins and transferrin were present. These findings support the hypothesis that the 17-α-acetoxy progestagens exert their major contraceptive action through an effect on the cervical mucus. In contrast, norgestrel at doses of 75 μg. probably has its major action by disturbing ovarian steroidogenesis. It is concluded that the “serum-like” proteins might play a significant role as a cross-linking agent between the thread-like glycoproteins. It is suggested that studies of the protein changes in the cervical mucus during administration of various progestational agents in relation to their effects on hormone output, might be applied in the search for a contraceptive with an optimal cervical mucus effect." @default.
• W2005694530 created "2016-06-24" @default.
• W2005694530 creator A5076063136 @default.
• W2005694530 date "1970-05-01" @default.
• W2005694530 modified "2023-10-16" @default.
• W2005694530 title "THE PROTEINS OF CERVICAL MUCUS AND THE INFLUENCE OF PROGESTAGENS" @default.
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• W2005694530 doi "https://doi.org/10.1111/j.1471-0528.1970.tb03547.x" @default.
• W2005694530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4193541" @default.
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