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- W2005696541 abstract "Pig and baboon xenotransplants in humans require assays that discriminate source from human cells to investigate engraftment and identify true infection of recipients with xenogeneic endogenous retroviruses. We developed two polymerase chain reaction assays that target a porcine-specific sequence in the beta-globin gene and a baboon-specific sequence in the mitochondrial cytochrome oxidase subunit II gene. The sensitivity and specificity of both assays were evaluated on DNA lysates from baboon, pig, and human peripheral blood lymphocytes. Both assays detected single cells in backgrounds of human DNA. Additionally, both assays were highly specific and yielded negative results in reactions containing only human DNA. The two assays reliably detected peripheral blood lymphocyte samples from 14 baboons and 16 pigs. The baboon- and pig-specific target sequences are gender independent and nonpolymorphic and allow universal applicability. The high sensitivity and specificity is of particular importance in assessing low-level engraftment in human xenotransplant chimeras." @default.
- W2005696541 created "2016-06-24" @default.
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- W2005696541 date "1996-11-01" @default.
- W2005696541 modified "2023-10-18" @default.
- W2005696541 title "HIGHLY SENSITIVE AND SPECIFIC POLYMERASE CHAIN REACTION ASSAYS FOR DETECTION OF BABOON AND PIG CELLS FOLLOWING XENOTRANSPLANTATION IN HUMANS" @default.
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- W2005696541 doi "https://doi.org/10.1097/00007890-199611150-00033" @default.
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