FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005697963> ?p ?o ?g. }

• W2005697963 endingPage "757" @default.
• W2005697963 startingPage "751" @default.
• W2005697963 abstract "Nasopharyngeal carcinoma (NPC) is multifactorial, and the genetic background may be a crucial etiologic factor. Interleukin-12 (IL-12) is a multifunctional cytokine that induces interferon (IFN)-gamma secretion and plays an important role in antitumor immunity. Interleukin-27 (IL-27) is a novel IL-12 family member, the present studies demonstrate that IL-27 mediates potent antitumor activity. Variations in the DNA sequence in the IL-12 and IL-27 gene may lead to altered cytokines production and/or activity, and so this can modulate an individual's susceptibility to NPC. To test this hypothesis, we investigated the relationship of IL-12 and IL-27 gene polymorphisms and NPC in a Chinese population. We analyzed single nucleotide polymorphisms (SNPs) of IL-12 gene 16974 A/C and IL-27 gene −964 A/G, 2905 T/G, 4730 T/C in 302 patients with NPC and 310 age- and sex-matched controls, using polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) and DNA sequencing methods. There were significant differences in the genotype and allele distribution of 16974 A/C polymorphism of the IL-12 gene among cases and controls. The 16974 CC and AC genotypes were associated with a significantly increased risk of NPC as compared with the 16974 AA genotypes (OR = 2.225, 95% CI 1.395–3.549, P = 0.001 and OR = 1.834, 95% CI 1.239–2.716, P = 0.002, respectively). The 16974 C allele was associated with a significantly increased risk of NPC as compared with the 16974 A allele (OR = 1.334, 95% CI 1.065–1.670, P = 0.012). However, genotype and allele frequencies of the IL-27 gene −964 A/G, 2905 T/G, 4730 T/C polymorphisms in NPC patients were not significantly different than that in healthy controls (P > 0.05). Our data suggest that IL-12 gene may play a role in the development of NPC. © 2009 Wiley-Liss, Inc." @default.
• W2005697963 created "2016-06-24" @default.
• W2005697963 creator A5010614651 @default.
• W2005697963 creator A5017070668 @default.
• W2005697963 creator A5038037078 @default.
• W2005697963 creator A5078739680 @default.
• W2005697963 creator A5080250649 @default.
• W2005697963 date "2009-08-01" @default.
• W2005697963 modified "2023-10-12" @default.
• W2005697963 title "Association of variants in the interleukin-27 and interleukin-12 gene with nasopharyngeal carcinoma" @default.
• W2005697963 cites W1488600638 @default.
• W2005697963 cites W1903378835 @default.
• W2005697963 cites W1964470959 @default.
• W2005697963 cites W1965023288 @default.
• W2005697963 cites W1965421847 @default.
• W2005697963 cites W1967407253 @default.
• W2005697963 cites W1967514279 @default.
• W2005697963 cites W1968918322 @default.
• W2005697963 cites W1970142265 @default.
• W2005697963 cites W1972563680 @default.
• W2005697963 cites W1979349547 @default.
• W2005697963 cites W1987010297 @default.
• W2005697963 cites W1988891003 @default.
• W2005697963 cites W2001034231 @default.
• W2005697963 cites W2008335027 @default.
• W2005697963 cites W2009817047 @default.
• W2005697963 cites W2010548598 @default.
• W2005697963 cites W2011960130 @default.
• W2005697963 cites W2019638146 @default.
• W2005697963 cites W2030447006 @default.
• W2005697963 cites W2030505452 @default.
• W2005697963 cites W2032374972 @default.
• W2005697963 cites W2035027025 @default.
• W2005697963 cites W2038721890 @default.
• W2005697963 cites W2041675187 @default.
• W2005697963 cites W2045640594 @default.
• W2005697963 cites W2058116408 @default.
• W2005697963 cites W2069249077 @default.
• W2005697963 cites W2071311617 @default.
• W2005697963 cites W2073431012 @default.
• W2005697963 cites W2086589495 @default.
• W2005697963 cites W2088685382 @default.
• W2005697963 cites W2091296471 @default.
• W2005697963 cites W2110755408 @default.
• W2005697963 cites W2116579183 @default.
• W2005697963 cites W2117726975 @default.
• W2005697963 cites W2118512649 @default.
• W2005697963 cites W2118546838 @default.
• W2005697963 cites W2126197815 @default.
• W2005697963 cites W2133439754 @default.
• W2005697963 cites W2134756173 @default.
• W2005697963 cites W2149473602 @default.
• W2005697963 cites W2150192496 @default.
• W2005697963 cites W2162559010 @default.
• W2005697963 cites W2166153412 @default.
• W2005697963 cites W2166182274 @default.
• W2005697963 cites W2184001542 @default.
• W2005697963 cites W2188809253 @default.
• W2005697963 cites W2322229996 @default.
• W2005697963 doi "https://doi.org/10.1002/mc.20522" @default.
• W2005697963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19148899" @default.
• W2005697963 hasPublicationYear "2009" @default.
• W2005697963 type Work @default.
• W2005697963 sameAs 2005697963 @default.
• W2005697963 citedByCount "45" @default.
• W2005697963 countsByYear W20056979632012 @default.
• W2005697963 countsByYear W20056979632013 @default.
• W2005697963 countsByYear W20056979632014 @default.
• W2005697963 countsByYear W20056979632015 @default.
• W2005697963 countsByYear W20056979632016 @default.
• W2005697963 countsByYear W20056979632017 @default.
• W2005697963 countsByYear W20056979632018 @default.
• W2005697963 countsByYear W20056979632019 @default.
• W2005697963 countsByYear W20056979632020 @default.
• W2005697963 crossrefType "journal-article" @default.
• W2005697963 hasAuthorship W2005697963A5010614651 @default.
• W2005697963 hasAuthorship W2005697963A5017070668 @default.
• W2005697963 hasAuthorship W2005697963A5038037078 @default.
• W2005697963 hasAuthorship W2005697963A5078739680 @default.
• W2005697963 hasAuthorship W2005697963A5080250649 @default.
• W2005697963 hasConcept C104317684 @default.
• W2005697963 hasConcept C126322002 @default.
• W2005697963 hasConcept C135763542 @default.
• W2005697963 hasConcept C153209595 @default.
• W2005697963 hasConcept C153911025 @default.
• W2005697963 hasConcept C168007829 @default.
• W2005697963 hasConcept C180754005 @default.
• W2005697963 hasConcept C203014093 @default.
• W2005697963 hasConcept C2778690821 @default.
• W2005697963 hasConcept C2778997737 @default.
• W2005697963 hasConcept C37463918 @default.
• W2005697963 hasConcept C509974204 @default.
• W2005697963 hasConcept C54355233 @default.
• W2005697963 hasConcept C71924100 @default.
• W2005697963 hasConcept C74172505 @default.
• W2005697963 hasConcept C86803240 @default.
• W2005697963 hasConceptScore W2005697963C104317684 @default.
• W2005697963 hasConceptScore W2005697963C126322002 @default.

• next