FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005698300> ?p ?o ?g. }

• W2005698300 endingPage "1175" @default.
• W2005698300 startingPage "1166" @default.
• W2005698300 abstract "The response of motor proteins to external loads underlies their ability to work in teams and determines the net speed and directionality of cargo transport. The mammalian kinesin-2, KIF3A/B, is a heterotrimeric motor involved in intraflagellar transport and vesicle motility in neurons. Bidirectional cargo transport is known to result from the opposing activities of KIF3A/B and dynein bound to the same cargo, but the load-dependent properties of kinesin-2 are poorly understood. We used a feedback-controlled optical trap to probe the velocity, run length, and unbinding kinetics of mouse KIF3A/B under various loads and nucleotide conditions. The kinesin-2 motor velocity is less sensitive than kinesin-1 to external forces, but its processivity diminishes steeply with load, and the motor was observed occasionally to slip and reattach. Each motor domain was characterized by studying homodimeric constructs, and a global fit to the data resulted in a comprehensive pathway that quantifies the principal force-dependent kinetic transitions. The properties of the KIF3A/B heterodimer are intermediate between the two homodimers, and the distinct load-dependent behavior is attributable to the properties of the motor domains and not to the neck linkers or the coiled-coil stalk. We conclude that the force-dependent movement of KIF3A/B differs significantly from conventional kinesin-1. Against opposing dynein forces, KIF3A/B motors are predicted to rapidly unbind and rebind, resulting in qualitatively different transport behavior from kinesin-1." @default.
• W2005698300 created "2016-06-24" @default.
• W2005698300 creator A5007662018 @default.
• W2005698300 creator A5047173144 @default.
• W2005698300 creator A5057753299 @default.
• W2005698300 creator A5085429881 @default.
• W2005698300 date "2015-05-01" @default.
• W2005698300 modified "2023-09-24" @default.
• W2005698300 title "The Mechanochemical Cycle of Mammalian Kinesin-2 KIF3A/B under Load" @default.
• W2005698300 cites W1487659884 @default.
• W2005698300 cites W1593716142 @default.
• W2005698300 cites W1618955965 @default.
• W2005698300 cites W1966790730 @default.
• W2005698300 cites W1968393513 @default.
• W2005698300 cites W1972398314 @default.
• W2005698300 cites W1996567147 @default.
• W2005698300 cites W1998198313 @default.
• W2005698300 cites W1998885514 @default.
• W2005698300 cites W1999250123 @default.
• W2005698300 cites W2005938853 @default.
• W2005698300 cites W2010018522 @default.
• W2005698300 cites W2019341264 @default.
• W2005698300 cites W2019606851 @default.
• W2005698300 cites W2026245994 @default.
• W2005698300 cites W2029448351 @default.
• W2005698300 cites W2032261838 @default.
• W2005698300 cites W2033859483 @default.
• W2005698300 cites W2044730950 @default.
• W2005698300 cites W2052192720 @default.
• W2005698300 cites W2052999972 @default.
• W2005698300 cites W2056648746 @default.
• W2005698300 cites W2057733928 @default.
• W2005698300 cites W2059438324 @default.
• W2005698300 cites W2061803377 @default.
• W2005698300 cites W2078056153 @default.
• W2005698300 cites W2080111827 @default.
• W2005698300 cites W2086730491 @default.
• W2005698300 cites W2086964976 @default.
• W2005698300 cites W2089611860 @default.
• W2005698300 cites W2092513547 @default.
• W2005698300 cites W2113170636 @default.
• W2005698300 cites W2126560028 @default.
• W2005698300 cites W2133737876 @default.
• W2005698300 cites W2145684136 @default.
• W2005698300 cites W2149312421 @default.
• W2005698300 cites W2151130369 @default.
• W2005698300 cites W2152516404 @default.
• W2005698300 cites W2158190317 @default.
• W2005698300 cites W2159740254 @default.
• W2005698300 cites W2168701582 @default.
• W2005698300 doi "https://doi.org/10.1016/j.cub.2015.03.013" @default.
• W2005698300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4422762" @default.
• W2005698300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25866395" @default.
• W2005698300 hasPublicationYear "2015" @default.
• W2005698300 type Work @default.
• W2005698300 sameAs 2005698300 @default.
• W2005698300 citedByCount "74" @default.
• W2005698300 countsByYear W20056983002015 @default.
• W2005698300 countsByYear W20056983002016 @default.
• W2005698300 countsByYear W20056983002017 @default.
• W2005698300 countsByYear W20056983002018 @default.
• W2005698300 countsByYear W20056983002019 @default.
• W2005698300 countsByYear W20056983002020 @default.
• W2005698300 countsByYear W20056983002021 @default.
• W2005698300 countsByYear W20056983002022 @default.
• W2005698300 countsByYear W20056983002023 @default.
• W2005698300 crossrefType "journal-article" @default.
• W2005698300 hasAuthorship W2005698300A5007662018 @default.
• W2005698300 hasAuthorship W2005698300A5047173144 @default.
• W2005698300 hasAuthorship W2005698300A5057753299 @default.
• W2005698300 hasAuthorship W2005698300A5085429881 @default.
• W2005698300 hasBestOaLocation W20056983001 @default.
• W2005698300 hasConcept C106987784 @default.
• W2005698300 hasConcept C115811362 @default.
• W2005698300 hasConcept C120665830 @default.
• W2005698300 hasConcept C121332964 @default.
• W2005698300 hasConcept C12554922 @default.
• W2005698300 hasConcept C131140672 @default.
• W2005698300 hasConcept C160408235 @default.
• W2005698300 hasConcept C181199279 @default.
• W2005698300 hasConcept C20198109 @default.
• W2005698300 hasConcept C20418707 @default.
• W2005698300 hasConcept C29648211 @default.
• W2005698300 hasConcept C37590093 @default.
• W2005698300 hasConcept C523546767 @default.
• W2005698300 hasConcept C54355233 @default.
• W2005698300 hasConcept C55493867 @default.
• W2005698300 hasConcept C58207958 @default.
• W2005698300 hasConcept C59006786 @default.
• W2005698300 hasConcept C82381507 @default.
• W2005698300 hasConcept C86803240 @default.
• W2005698300 hasConcept C93126451 @default.
• W2005698300 hasConcept C95444343 @default.
• W2005698300 hasConceptScore W2005698300C106987784 @default.
• W2005698300 hasConceptScore W2005698300C115811362 @default.
• W2005698300 hasConceptScore W2005698300C120665830 @default.
• W2005698300 hasConceptScore W2005698300C121332964 @default.
• W2005698300 hasConceptScore W2005698300C12554922 @default.

• next