FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005703489> ?p ?o ?g. }

• W2005703489 abstract "Over a 24-year period, 137 patients were referred for management of newly diagnosed chronic lymphocytic leukemia. One hundred and nineteen patients have been reviewed in terms of response to therapy and prognostic factors for survival; 18 patients were excluded either because lymph node biopsy was not compatible with the diagnosis of CLL (11 patients), or because the lymphocyte count at presentation was < 5 x 10(9)/l (seven patients). Patients were staged retrospectively according to both the Rai and Binet Classifications. Forty-eight per cent (57/119) were deemed not to be in need of any treatment at presentation, 36 per cent (43/119) have never received any specific therapy. The majority of patients received chlorambucil alone, at a dose of 10 mg daily given for 6 weeks, followed by a 2-week interval, followed by three, 2-week cycles. The overall response rate (complete+partial remission) was 38 per cent. In terms of survival, there was a trend in favour of patients who responded to treatment in comparison with those who did not but this did not reach statistical significance (P = 0.07). Correlations with stage were highly significant, the median survivals for patients with stage A, B and C disease (Binet) were 12.5, 8 and 3.5 years respectively. On univariate analysis, the absolute lymphocyte count at presentation was the most significant prognostic factor for survival, patients presenting with an absolute lymphocyte count above 50 x 10(9)/l having a less favourable prognosis (P = 0.002). However, on multivariate analysis, older age, a low hemoglobin, low platelet count, and the presence of lymphadenopathy and fever at presentation correlated adversely with survival. Overall, 40 patients died as a consequence of CLL or from disease-related causes, 34/40 dying of infection. Twenty-one patients developed second cancers. With a median follow-up of 13 years, these results confirm that the two staging systems can separate patients into prognostic groups, however in practice, there is heterogeneity of outcome within stage. New approaches are urgently needed." @default.
• W2005703489 created "2016-06-24" @default.
• W2005703489 creator A5009844374 @default.
• W2005703489 creator A5019626512 @default.
• W2005703489 creator A5025307148 @default.
• W2005703489 creator A5030399738 @default.
• W2005703489 creator A5052024539 @default.
• W2005703489 creator A5054909642 @default.
• W2005703489 creator A5064818132 @default.
• W2005703489 creator A5069757680 @default.
• W2005703489 date "1994-01-01" @default.
• W2005703489 modified "2023-09-24" @default.
• W2005703489 title "The management of chronic lymphocytic leukemia at a single centre over a 24-year period: prognostic factors for survival" @default.
• W2005703489 cites W1484886449 @default.
• W2005703489 cites W1501443642 @default.
• W2005703489 cites W154103547 @default.
• W2005703489 cites W1710792668 @default.
• W2005703489 cites W1756818535 @default.
• W2005703489 cites W1792577025 @default.
• W2005703489 cites W1862276309 @default.
• W2005703489 cites W1873031565 @default.
• W2005703489 cites W1965851569 @default.
• W2005703489 cites W1984134914 @default.
• W2005703489 cites W1998770107 @default.
• W2005703489 cites W1999372457 @default.
• W2005703489 cites W2035858908 @default.
• W2005703489 cites W2038252730 @default.
• W2005703489 cites W2041500483 @default.
• W2005703489 cites W2061351840 @default.
• W2005703489 cites W2064099782 @default.
• W2005703489 cites W2072566254 @default.
• W2005703489 cites W2102552995 @default.
• W2005703489 cites W2226417367 @default.
• W2005703489 cites W2269047739 @default.
• W2005703489 cites W2270662807 @default.
• W2005703489 cites W2277594521 @default.
• W2005703489 cites W2317201497 @default.
• W2005703489 cites W4229737605 @default.
• W2005703489 cites W4233161682 @default.
• W2005703489 cites W4233718653 @default.
• W2005703489 cites W4238310152 @default.
• W2005703489 cites W4246675764 @default.
• W2005703489 cites W4247212520 @default.
• W2005703489 cites W4255040254 @default.
• W2005703489 cites W4293241248 @default.
• W2005703489 doi "https://doi.org/10.1002/hon.2900120105" @default.
• W2005703489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7515019" @default.
• W2005703489 hasPublicationYear "1994" @default.
• W2005703489 type Work @default.
• W2005703489 sameAs 2005703489 @default.
• W2005703489 citedByCount "18" @default.
• W2005703489 countsByYear W20057034892012 @default.
• W2005703489 countsByYear W20057034892013 @default.
• W2005703489 countsByYear W20057034892015 @default.
• W2005703489 countsByYear W20057034892020 @default.
• W2005703489 crossrefType "journal-article" @default.
• W2005703489 hasAuthorship W2005703489A5009844374 @default.
• W2005703489 hasAuthorship W2005703489A5019626512 @default.
• W2005703489 hasAuthorship W2005703489A5025307148 @default.
• W2005703489 hasAuthorship W2005703489A5030399738 @default.
• W2005703489 hasAuthorship W2005703489A5052024539 @default.
• W2005703489 hasAuthorship W2005703489A5054909642 @default.
• W2005703489 hasAuthorship W2005703489A5064818132 @default.
• W2005703489 hasAuthorship W2005703489A5069757680 @default.
• W2005703489 hasConcept C126322002 @default.
• W2005703489 hasConcept C141071460 @default.
• W2005703489 hasConcept C144301174 @default.
• W2005703489 hasConcept C146357865 @default.
• W2005703489 hasConcept C151730666 @default.
• W2005703489 hasConcept C2776694085 @default.
• W2005703489 hasConcept C2776755627 @default.
• W2005703489 hasConcept C2777866208 @default.
• W2005703489 hasConcept C2777938653 @default.
• W2005703489 hasConcept C2778461978 @default.
• W2005703489 hasConcept C38180746 @default.
• W2005703489 hasConcept C71924100 @default.
• W2005703489 hasConcept C86803240 @default.
• W2005703489 hasConcept C90924648 @default.
• W2005703489 hasConceptScore W2005703489C126322002 @default.
• W2005703489 hasConceptScore W2005703489C141071460 @default.
• W2005703489 hasConceptScore W2005703489C144301174 @default.
• W2005703489 hasConceptScore W2005703489C146357865 @default.
• W2005703489 hasConceptScore W2005703489C151730666 @default.
• W2005703489 hasConceptScore W2005703489C2776694085 @default.
• W2005703489 hasConceptScore W2005703489C2776755627 @default.
• W2005703489 hasConceptScore W2005703489C2777866208 @default.
• W2005703489 hasConceptScore W2005703489C2777938653 @default.
• W2005703489 hasConceptScore W2005703489C2778461978 @default.
• W2005703489 hasConceptScore W2005703489C38180746 @default.
• W2005703489 hasConceptScore W2005703489C71924100 @default.
• W2005703489 hasConceptScore W2005703489C86803240 @default.
• W2005703489 hasConceptScore W2005703489C90924648 @default.
• W2005703489 hasLocation W20057034891 @default.
• W2005703489 hasLocation W20057034892 @default.
• W2005703489 hasOpenAccess W2005703489 @default.
• W2005703489 hasPrimaryLocation W20057034891 @default.
• W2005703489 hasRelatedWork W1964742152 @default.
• W2005703489 hasRelatedWork W2033758025 @default.
• W2005703489 hasRelatedWork W2139353369 @default.
• W2005703489 hasRelatedWork W2210447462 @default.

• next