FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005706019> ?p ?o ?g. }

• W2005706019 endingPage "99" @default.
• W2005706019 startingPage "91" @default.
• W2005706019 abstract "Macrophages (MΦ) and smooth muscle cells (SMC) are transformed into foam cells by massive accumulation of modified lipoproteins during atherogenesis. It is known that class AI/II scavenger receptors participate in the foam cell formation of MΦ. The mechanism of lipid accumulation in SMC is however unknown. Therefore, we investigated if class AI/II scavenger receptors mediate the uptake of modified lipoproteins in SMC. Additionally, we examined the influence of MΦ and proinflammatory cytokines in this process. Our flow cytometric experiments revealed significant uptake of DiI-AcLDL in SMC. This uptake was markedly enhanced by IL-1α and TNF-α, whereas cocultured MΦ decreased the uptake of DiI-AcLDL in SMC. Competition and blocking experiments were performed to enlighten the role of class AI/II scavenger receptors. The competition experiments showed that surplus NatLDL, a ligand not known to interact with class AI/II scavenger receptors, caused a drastically decreased uptake of DiI-AcLDL in SMC. Additionally, blocking of class AI/II scavenger receptors with antibody 2F8 did not influence the uptake of DiI-AcLDL in SMC. Furthermore, fluorescence microscopic double staining of human coronary arteries with early, intermediate and advanced atherosclerotic lesions showed no colocalization of class AI scavenger receptors with SMC. These results indicate that class AI/II scavenger receptors play only a minor role in the uptake of modified lipoproteins in SMC. We suggest that SMC foam cell formation is mainly mediated by other receptors than class AI/II scavenger receptors." @default.
• W2005706019 created "2016-06-24" @default.
• W2005706019 creator A5005879874 @default.
• W2005706019 creator A5006492057 @default.
• W2005706019 creator A5039089468 @default.
• W2005706019 creator A5069237475 @default.
• W2005706019 creator A5073657981 @default.
• W2005706019 date "2008-02-01" @default.
• W2005706019 modified "2023-10-17" @default.
• W2005706019 title "Function of scavenger receptor class A type I/II is not important for smooth muscle foam cell formation" @default.
• W2005706019 cites W1497439699 @default.
• W2005706019 cites W176599066 @default.
• W2005706019 cites W1971523668 @default.
• W2005706019 cites W1984393490 @default.
• W2005706019 cites W1989556210 @default.
• W2005706019 cites W2013341934 @default.
• W2005706019 cites W2020871089 @default.
• W2005706019 cites W2027816266 @default.
• W2005706019 cites W2043240855 @default.
• W2005706019 cites W2043456569 @default.
• W2005706019 cites W2045180319 @default.
• W2005706019 cites W2052283634 @default.
• W2005706019 cites W2063329261 @default.
• W2005706019 cites W2087797124 @default.
• W2005706019 cites W2089581497 @default.
• W2005706019 cites W2107611361 @default.
• W2005706019 cites W2115017173 @default.
• W2005706019 cites W2115268091 @default.
• W2005706019 cites W2116716023 @default.
• W2005706019 cites W2118877270 @default.
• W2005706019 cites W2134605118 @default.
• W2005706019 cites W2135096311 @default.
• W2005706019 cites W2135364407 @default.
• W2005706019 cites W2154535057 @default.
• W2005706019 cites W2165235458 @default.
• W2005706019 cites W2417115269 @default.
• W2005706019 cites W40251019 @default.
• W2005706019 doi "https://doi.org/10.1016/j.ejcb.2007.08.004" @default.
• W2005706019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17980455" @default.
• W2005706019 hasPublicationYear "2008" @default.
• W2005706019 type Work @default.
• W2005706019 sameAs 2005706019 @default.
• W2005706019 citedByCount "5" @default.
• W2005706019 countsByYear W20057060192016 @default.
• W2005706019 countsByYear W20057060192018 @default.
• W2005706019 countsByYear W20057060192021 @default.
• W2005706019 countsByYear W20057060192022 @default.
• W2005706019 crossrefType "journal-article" @default.
• W2005706019 hasAuthorship W2005706019A5005879874 @default.
• W2005706019 hasAuthorship W2005706019A5006492057 @default.
• W2005706019 hasAuthorship W2005706019A5039089468 @default.
• W2005706019 hasAuthorship W2005706019A5069237475 @default.
• W2005706019 hasAuthorship W2005706019A5073657981 @default.
• W2005706019 hasConcept C12554922 @default.
• W2005706019 hasConcept C153911025 @default.
• W2005706019 hasConcept C170493617 @default.
• W2005706019 hasConcept C185592680 @default.
• W2005706019 hasConcept C2777895019 @default.
• W2005706019 hasConcept C2778163477 @default.
• W2005706019 hasConcept C2780072125 @default.
• W2005706019 hasConcept C41443022 @default.
• W2005706019 hasConcept C55493867 @default.
• W2005706019 hasConcept C86803240 @default.
• W2005706019 hasConcept C95444343 @default.
• W2005706019 hasConceptScore W2005706019C12554922 @default.
• W2005706019 hasConceptScore W2005706019C153911025 @default.
• W2005706019 hasConceptScore W2005706019C170493617 @default.
• W2005706019 hasConceptScore W2005706019C185592680 @default.
• W2005706019 hasConceptScore W2005706019C2777895019 @default.
• W2005706019 hasConceptScore W2005706019C2778163477 @default.
• W2005706019 hasConceptScore W2005706019C2780072125 @default.
• W2005706019 hasConceptScore W2005706019C41443022 @default.
• W2005706019 hasConceptScore W2005706019C55493867 @default.
• W2005706019 hasConceptScore W2005706019C86803240 @default.
• W2005706019 hasConceptScore W2005706019C95444343 @default.
• W2005706019 hasIssue "2" @default.
• W2005706019 hasLocation W20057060191 @default.
• W2005706019 hasLocation W20057060192 @default.
• W2005706019 hasOpenAccess W2005706019 @default.
• W2005706019 hasPrimaryLocation W20057060191 @default.
• W2005706019 hasRelatedWork W1998240747 @default.
• W2005706019 hasRelatedWork W2005706019 @default.
• W2005706019 hasRelatedWork W2038445236 @default.
• W2005706019 hasRelatedWork W2039344988 @default.
• W2005706019 hasRelatedWork W2043240855 @default.
• W2005706019 hasRelatedWork W2123177387 @default.
• W2005706019 hasRelatedWork W2157490824 @default.
• W2005706019 hasRelatedWork W2354004977 @default.
• W2005706019 hasRelatedWork W2408826154 @default.
• W2005706019 hasRelatedWork W2594847036 @default.
• W2005706019 hasVolume "87" @default.
• W2005706019 isParatext "false" @default.
• W2005706019 isRetracted "false" @default.
• W2005706019 magId "2005706019" @default.
• W2005706019 workType "article" @default.