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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005706069> ?p ?o ?g. }

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• W2005706069 abstract "Poly(adenosine 5'-diphosphoribose) synthetase (PARS) is a nuclear enzyme which, when activated by DNA strand breaks, adds up to 100 adenosine 5'-diphosphoribose (ADP-ribose) units to nuclear proteins such as histones and PARS itself. This activation can lead to cell death through depletion of beta-nicotinamide adenine dinucleotide (the source of ADP-ribose) and adenosine triphosphate. Nitric oxide (NO) stimulated ADP-ribosylation of PARS in rat brain. Benzamide and other derivatives, which inhibit PARS, blocked N-methyl-D-aspartate- and NO-mediated neurotoxicity with relative potencies paralleling their ability to inhibit PARS. Thus, NO appeared to elicit neurotoxicity by activating PARS." @default.
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• W2005706069 date "1994-02-04" @default.
• W2005706069 modified "2023-10-10" @default.
• W2005706069 title "Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity" @default.
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• W2005706069 doi "https://doi.org/10.1126/science.8080500" @default.
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