Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005706618> ?p ?o ?g. }
- W2005706618 endingPage "3062" @default.
- W2005706618 startingPage "3050" @default.
- W2005706618 abstract "An efficient means of identifying protein biomarkers is essential to proper cancer management. A well-characterized proteome resource holds special promise for the discovery of novel biomarkers. However, quantification of the differences between physiological conditions together with deep down profiling has become increasingly challenging in proteomics. Here, we perform expression profiling of the colorectal cancer (CRC) proteome by stable isotope labeling and mass spectrometry. Quantitative analysis included performing mTRAQ and cICAT labeling in a pooled sample of three microsatellite stable (MSS) type CRC tissues and a pooled sample of their matched normal tissues. We identified and quantified a total of 3688 proteins. Among them, 1487 proteins were expressed differentially between normal and cancer tissues by higher than 2-fold; 1009 proteins showed increased expression in cancer tissue, whereas 478 proteins showed decreased expression. Bioinformatic analysis revealed that our data were largely consistent with known CRC relevant signaling pathways, such as the Wnt/β-catenin, caveolar-mediated endocytosis, and RAN signaling pathways. Mitochondrial dysfunction, known as the Waburg hypothesis, was also confirmed. Therefore, our data showing alterations in the proteomic profile of CRC constitutes a useful resource that may provide insights into tumor progression with later goal of identifying biologically and clinically relevant marker proteins. This article is part of a Special Issue entitled: Proteomics: The clinical link." @default.
- W2005706618 created "2016-06-24" @default.
- W2005706618 creator A5002440433 @default.
- W2005706618 creator A5019576809 @default.
- W2005706618 creator A5026148041 @default.
- W2005706618 creator A5028661392 @default.
- W2005706618 creator A5032439705 @default.
- W2005706618 date "2012-06-01" @default.
- W2005706618 modified "2023-09-26" @default.
- W2005706618 title "Expression profiling of more than 3500 proteins of MSS-type colorectal cancer by stable isotope labeling and mass spectrometry" @default.
- W2005706618 cites W1518252063 @default.
- W2005706618 cites W1802480460 @default.
- W2005706618 cites W1971804207 @default.
- W2005706618 cites W1976806248 @default.
- W2005706618 cites W1978555671 @default.
- W2005706618 cites W1986986419 @default.
- W2005706618 cites W1997982024 @default.
- W2005706618 cites W2008476583 @default.
- W2005706618 cites W2010548624 @default.
- W2005706618 cites W2011912935 @default.
- W2005706618 cites W2012802011 @default.
- W2005706618 cites W2016543331 @default.
- W2005706618 cites W2018690353 @default.
- W2005706618 cites W2019049058 @default.
- W2005706618 cites W2023695022 @default.
- W2005706618 cites W2025206606 @default.
- W2005706618 cites W2031469256 @default.
- W2005706618 cites W2038809664 @default.
- W2005706618 cites W2050790000 @default.
- W2005706618 cites W2051261215 @default.
- W2005706618 cites W2052252017 @default.
- W2005706618 cites W2070842899 @default.
- W2005706618 cites W2072451410 @default.
- W2005706618 cites W2072451938 @default.
- W2005706618 cites W2073386315 @default.
- W2005706618 cites W2073575984 @default.
- W2005706618 cites W2074584459 @default.
- W2005706618 cites W2077440316 @default.
- W2005706618 cites W2086216615 @default.
- W2005706618 cites W2090551359 @default.
- W2005706618 cites W2092787533 @default.
- W2005706618 cites W2094999310 @default.
- W2005706618 cites W2095482824 @default.
- W2005706618 cites W2096579722 @default.
- W2005706618 cites W2099409120 @default.
- W2005706618 cites W2100251163 @default.
- W2005706618 cites W2105698254 @default.
- W2005706618 cites W2111208057 @default.
- W2005706618 cites W2115701133 @default.
- W2005706618 cites W2121495964 @default.
- W2005706618 cites W2123471748 @default.
- W2005706618 cites W2132764178 @default.
- W2005706618 cites W2149506097 @default.
- W2005706618 cites W2157452165 @default.
- W2005706618 cites W2172064884 @default.
- W2005706618 doi "https://doi.org/10.1016/j.jprot.2011.11.021" @default.
- W2005706618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22154799" @default.
- W2005706618 hasPublicationYear "2012" @default.
- W2005706618 type Work @default.
- W2005706618 sameAs 2005706618 @default.
- W2005706618 citedByCount "31" @default.
- W2005706618 countsByYear W20057066182012 @default.
- W2005706618 countsByYear W20057066182013 @default.
- W2005706618 countsByYear W20057066182014 @default.
- W2005706618 countsByYear W20057066182015 @default.
- W2005706618 countsByYear W20057066182016 @default.
- W2005706618 countsByYear W20057066182017 @default.
- W2005706618 countsByYear W20057066182019 @default.
- W2005706618 countsByYear W20057066182020 @default.
- W2005706618 countsByYear W20057066182021 @default.
- W2005706618 countsByYear W20057066182023 @default.
- W2005706618 crossrefType "journal-article" @default.
- W2005706618 hasAuthorship W2005706618A5002440433 @default.
- W2005706618 hasAuthorship W2005706618A5019576809 @default.
- W2005706618 hasAuthorship W2005706618A5026148041 @default.
- W2005706618 hasAuthorship W2005706618A5028661392 @default.
- W2005706618 hasAuthorship W2005706618A5032439705 @default.
- W2005706618 hasConcept C104317684 @default.
- W2005706618 hasConcept C104397665 @default.
- W2005706618 hasConcept C121608353 @default.
- W2005706618 hasConcept C124535831 @default.
- W2005706618 hasConcept C137620995 @default.
- W2005706618 hasConcept C34905852 @default.
- W2005706618 hasConcept C46111723 @default.
- W2005706618 hasConcept C502942594 @default.
- W2005706618 hasConcept C526805850 @default.
- W2005706618 hasConcept C54355233 @default.
- W2005706618 hasConcept C60644358 @default.
- W2005706618 hasConcept C62478195 @default.
- W2005706618 hasConcept C70721500 @default.
- W2005706618 hasConcept C80311884 @default.
- W2005706618 hasConcept C86803240 @default.
- W2005706618 hasConcept C95444343 @default.
- W2005706618 hasConceptScore W2005706618C104317684 @default.
- W2005706618 hasConceptScore W2005706618C104397665 @default.
- W2005706618 hasConceptScore W2005706618C121608353 @default.
- W2005706618 hasConceptScore W2005706618C124535831 @default.
- W2005706618 hasConceptScore W2005706618C137620995 @default.