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• W2005710090 abstract "The syntheses of closo- and nido-carboranylchlorins 4 and 5 from a known carboranylporphyrin are described. Water-soluble nido-carboranylporphyrin 5 was found to have very low dark cytotoxicity (IC50 > 500 microM using a MTT-based assay) but to be toxic in the presence of red light (IC50 = 80 microM at 0.55 J/cm2 light dose). Under the same experimental conditions, carboranylchlorin 5 was taken up by human glioma T98G cells to a significantly higher extent than chlorin e6, a chlorophyll degradation product. The preferred sites of subcellular localization of carboranylchlorin 5 were found to be the cell lysosomes. Our results suggest that carboranylchlorin 5 is a promising new dual sensitizer for the PDT and BNCT treatment of tumors." @default.
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• W2005710090 date "2006-09-01" @default.
• W2005710090 modified "2023-09-30" @default.
• W2005710090 title "Synthesis and cellular studies of a carboranylchlorin for the PDT and BNCT of tumors" @default.
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• W2005710090 doi "https://doi.org/10.1016/j.bmc.2006.05.026" @default.
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