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- W2005712358 abstract "Thalassemia is a congenital hemolytic disorder caused by a partial or complete deficiency of α- or β-globin chain synthesis. Homozygous carriers of β-globin gene defects suffer from severe anemia and other serious complications from early childhood. The disease is treated by chronic blood transfusion. However, this can cause severe iron overload resulting in progressive organ failure. Some forms of α thalassemia are also associated with a similar clinical picture. Despite the difficulties associated with treatment, standards of care for thalassemic patients have improved in recent years, resulting in almost doubling of the average life expectancy. As a consequence, additional previously undescribed, complications are now being recognized. In particular, profound hemostatic changes have been observed in patients with β-thalassemia major (β-TM) and β-thalassemia intermedia (β-TI) and also in patients with α thalassemia (hemoglobin H disease). The presence of a higher than normal incidence of thromboembolic events, mainly in β-TI, and the existence of prothrombotic hemostatic anomalies in the majority of the patients, even from a very young age, have led to the recognition of the existence of a chronic hypercoagulable state in thalassemic patients. Despite the appearance of numerous publications on the frequent occurrence of thromboembolic complications in thalassemia, this complication has not been emphasized or comprehensively reviewed. This review summarizes the current literature and discusses possible mechanisms of the lifelong hypercoagulable state that exists in thalassemia." @default.
- W2005712358 created "2016-06-24" @default.
- W2005712358 creator A5019467798 @default.
- W2005712358 creator A5052997253 @default.
- W2005712358 date "2002-01-01" @default.
- W2005712358 modified "2023-10-13" @default.
- W2005712358 title "The hypercoagulable state in thalassemia" @default.
- W2005712358 cites W105021832 @default.
- W2005712358 cites W1527910795 @default.
- W2005712358 cites W1533635046 @default.
- W2005712358 cites W1584488227 @default.
- W2005712358 cites W181181137 @default.
- W2005712358 cites W187823094 @default.
- W2005712358 cites W196272636 @default.
- W2005712358 cites W1966562996 @default.
- W2005712358 cites W1972406498 @default.
- W2005712358 cites W1977685233 @default.
- W2005712358 cites W1977708103 @default.
- W2005712358 cites W1978934842 @default.
- W2005712358 cites W1981237191 @default.
- W2005712358 cites W1982805342 @default.
- W2005712358 cites W1982899101 @default.
- W2005712358 cites W1984230780 @default.
- W2005712358 cites W1984789764 @default.
- W2005712358 cites W1986646838 @default.
- W2005712358 cites W1990033742 @default.
- W2005712358 cites W1990047235 @default.
- W2005712358 cites W1990756535 @default.
- W2005712358 cites W1993539946 @default.
- W2005712358 cites W1994951969 @default.
- W2005712358 cites W1999024979 @default.
- W2005712358 cites W1999671191 @default.
- W2005712358 cites W2007391334 @default.
- W2005712358 cites W2008308892 @default.
- W2005712358 cites W2009304993 @default.
- W2005712358 cites W2012329069 @default.
- W2005712358 cites W2014826463 @default.
- W2005712358 cites W2017059296 @default.
- W2005712358 cites W2021414189 @default.
- W2005712358 cites W2031113061 @default.
- W2005712358 cites W2037460392 @default.
- W2005712358 cites W2038018968 @default.
- W2005712358 cites W2043541898 @default.
- W2005712358 cites W2048442039 @default.
- W2005712358 cites W2050985847 @default.
- W2005712358 cites W2051998014 @default.
- W2005712358 cites W2056349132 @default.
- W2005712358 cites W2060914259 @default.
- W2005712358 cites W2061809972 @default.
- W2005712358 cites W2061957698 @default.
- W2005712358 cites W2066405046 @default.
- W2005712358 cites W2067679776 @default.
- W2005712358 cites W2071347618 @default.
- W2005712358 cites W2075895818 @default.
- W2005712358 cites W2078135604 @default.
- W2005712358 cites W2078310868 @default.
- W2005712358 cites W2087401823 @default.
- W2005712358 cites W2090756137 @default.
- W2005712358 cites W2091102906 @default.
- W2005712358 cites W2091151022 @default.
- W2005712358 cites W2091938533 @default.
- W2005712358 cites W2098289478 @default.
- W2005712358 cites W2104641455 @default.
- W2005712358 cites W2112813064 @default.
- W2005712358 cites W2124952255 @default.
- W2005712358 cites W2154991846 @default.
- W2005712358 cites W2307329975 @default.
- W2005712358 cites W2310672476 @default.
- W2005712358 cites W2316102942 @default.
- W2005712358 cites W2319025455 @default.
- W2005712358 cites W2319834083 @default.
- W2005712358 cites W2330845108 @default.
- W2005712358 cites W2385480394 @default.
- W2005712358 cites W2413187562 @default.
- W2005712358 cites W2414239757 @default.
- W2005712358 cites W2773160569 @default.
- W2005712358 cites W3141197395 @default.
- W2005712358 cites W33416372 @default.
- W2005712358 cites W4236219361 @default.
- W2005712358 cites W4241878308 @default.
- W2005712358 cites W4255146758 @default.
- W2005712358 cites W4324263026 @default.
- W2005712358 cites W4361745155 @default.
- W2005712358 doi "https://doi.org/10.1182/blood.v99.1.36" @default.
- W2005712358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11756150" @default.
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