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• W2005719785 abstract "BackgroundUnderstanding the nature of environmental factors that contribute to behavioral health is critical for successful prevention strategies in individuals at risk for psychiatric disorders. These factors are typically experiential in nature, such as stress and urbanicity, but nutrition—in particular dietary deficiency of omega-3 polyunsaturated fatty acids (n-3 PUFAs)—has increasingly been implicated in the symptomatic onset of schizophrenia and mood disorders, which typically occurs during adolescence to early adulthood. Thus, adolescence might be the critical age range for the negative impact of diet as an environmental insult.MethodsA rat model involving consecutive generations of n-3 PUFA deficiency was developed on the basis of the assumption that dietary trends toward decreased consumption of these fats began 4–5 decades ago when the parents of current adolescents were born. Behavioral performance in a wide range of tasks as well as markers of dopamine-related neurotransmission was compared in adolescents and adults fed n-3 PUFA adequate and deficient diets.ResultsIn adolescents, dietary n-3 PUFA deficiency across consecutive generations produced a modality-selective and task-dependent impairment in cognitive and motivated behavior distinct from the deficits observed in adults. Although this dietary deficiency affected expression of dopamine-related proteins in both age groups in adolescents but not adults, there was an increase in tyrosine hydroxylase expression that was selective to the dorsal striatum.ConclusionsThese data support a nutritional contribution to optimal cognitive and affective functioning in adolescents. Furthermore, they suggest that n-3 PUFA deficiency disrupts adolescent behaviors through enhanced dorsal striatal dopamine availability. Understanding the nature of environmental factors that contribute to behavioral health is critical for successful prevention strategies in individuals at risk for psychiatric disorders. These factors are typically experiential in nature, such as stress and urbanicity, but nutrition—in particular dietary deficiency of omega-3 polyunsaturated fatty acids (n-3 PUFAs)—has increasingly been implicated in the symptomatic onset of schizophrenia and mood disorders, which typically occurs during adolescence to early adulthood. Thus, adolescence might be the critical age range for the negative impact of diet as an environmental insult. A rat model involving consecutive generations of n-3 PUFA deficiency was developed on the basis of the assumption that dietary trends toward decreased consumption of these fats began 4–5 decades ago when the parents of current adolescents were born. Behavioral performance in a wide range of tasks as well as markers of dopamine-related neurotransmission was compared in adolescents and adults fed n-3 PUFA adequate and deficient diets. In adolescents, dietary n-3 PUFA deficiency across consecutive generations produced a modality-selective and task-dependent impairment in cognitive and motivated behavior distinct from the deficits observed in adults. Although this dietary deficiency affected expression of dopamine-related proteins in both age groups in adolescents but not adults, there was an increase in tyrosine hydroxylase expression that was selective to the dorsal striatum. These data support a nutritional contribution to optimal cognitive and affective functioning in adolescents. Furthermore, they suggest that n-3 PUFA deficiency disrupts adolescent behaviors through enhanced dorsal striatal dopamine availability." @default.
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• W2005719785 date "2014-01-01" @default.
• W2005719785 modified "2023-09-23" @default.
• W2005719785 title "Adolescent Behavior and Dopamine Availability Are Uniquely Sensitive to Dietary Omega-3 Fatty Acid Deficiency" @default.
• W2005719785 cites W1489937832 @default.
• W2005719785 cites W1527753734 @default.
• W2005719785 cites W1531083788 @default.
• W2005719785 cites W1844088319 @default.
• W2005719785 cites W1854167840 @default.
• W2005719785 cites W1918679983 @default.
• W2005719785 cites W1968528693 @default.
• W2005719785 cites W1969217470 @default.
• W2005719785 cites W1971208324 @default.
• W2005719785 cites W1977423494 @default.
• W2005719785 cites W1979203936 @default.
• W2005719785 cites W1983202833 @default.
• W2005719785 cites W1986084664 @default.
• W2005719785 cites W1992786359 @default.
• W2005719785 cites W1995183462 @default.
• W2005719785 cites W1997659373 @default.
• W2005719785 cites W2003494755 @default.
• W2005719785 cites W2004481406 @default.
• W2005719785 cites W2006101031 @default.
• W2005719785 cites W2007928115 @default.
• W2005719785 cites W2011479449 @default.
• W2005719785 cites W2012007142 @default.
• W2005719785 cites W2012381088 @default.
• W2005719785 cites W2015479122 @default.
• W2005719785 cites W2016002102 @default.
• W2005719785 cites W2020326582 @default.
• W2005719785 cites W2032456267 @default.
• W2005719785 cites W2036621839 @default.
• W2005719785 cites W2037457092 @default.
• W2005719785 cites W2040073285 @default.
• W2005719785 cites W2040749203 @default.
• W2005719785 cites W2043427265 @default.
• W2005719785 cites W2045110077 @default.
• W2005719785 cites W2047016005 @default.
• W2005719785 cites W2047288594 @default.
• W2005719785 cites W2059809898 @default.
• W2005719785 cites W2063439136 @default.
• W2005719785 cites W2065207747 @default.
• W2005719785 cites W2067275984 @default.
• W2005719785 cites W2068254130 @default.
• W2005719785 cites W2076925259 @default.
• W2005719785 cites W2089100905 @default.
• W2005719785 cites W2092687109 @default.
• W2005719785 cites W2098447413 @default.
• W2005719785 cites W2108479409 @default.
• W2005719785 cites W2118964451 @default.
• W2005719785 cites W2130372506 @default.
• W2005719785 cites W2132025144 @default.
• W2005719785 cites W2132485329 @default.
• W2005719785 cites W2148954819 @default.
• W2005719785 cites W2154058918 @default.
• W2005719785 cites W2156333779 @default.
• W2005719785 cites W2157657177 @default.
• W2005719785 cites W2157844171 @default.
• W2005719785 cites W2158052449 @default.
• W2005719785 cites W2160985876 @default.
• W2005719785 cites W2168526937 @default.
• W2005719785 cites W2170415351 @default.
• W2005719785 cites W2186820760 @default.
• W2005719785 cites W2320076638 @default.
• W2005719785 doi "https://doi.org/10.1016/j.biopsych.2013.06.007" @default.
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