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• W2005725217 startingPage "12191" @default.
• W2005725217 abstract "The transcriptional activity of an in vitro assembled human interferon-beta gene enhanceosome is highly synergistic. This synergy requires five distinct transcriptional activator proteins (ATF2/c-JUN, interferon regulatory factor 1, and p50/p65 of NF-kappaB), the high mobility group protein HMG I(Y), and the correct alignment of protein-binding sites on the face of the DNA double helix. Here, we investigate the mechanisms of enhanceosome-dependent transcriptional synergy during preinitiation complex assembly in vitro. We show that the stereospecific assembly of the enhanceosome is critical for the efficient recruitment of TFIIB into a template-committed TFIID-TFIIA-USA (upstream stimulatory activity complex) and for the subsequent recruitment of the RNA polymerase II holoenzyme complex. In addition, we provide evidence that recruitment of the holoenzyme by the enhanceosome is due, at least in part, to interactions between the enhanceosome and the transcriptional coactivator CREB, cAMP responsive element binding protein (CBP). These studies reveal a unique role of enhanceosomes in the cooperative assembly of the transcription machinery on the human interferon-beta promoter." @default.
• W2005725217 created "2016-06-24" @default.
• W2005725217 creator A5020742231 @default.
• W2005725217 creator A5041455638 @default.
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• W2005725217 date "1998-10-13" @default.
• W2005725217 modified "2023-10-18" @default.
• W2005725217 title "Efficient recruitment of TFIIB and CBP-RNA polymerase II holoenzyme by an interferon-β enhanceosome <i>in vitro</i>" @default.
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• W2005725217 doi "https://doi.org/10.1073/pnas.95.21.12191" @default.
• W2005725217 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/22807" @default.
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