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- W2005734679 abstract "We have discovered that the immune system processes proopiomelanocortin (POMC) products differently depending on the stimulus for induction. We have shown that corticotropin-releasing factor (CRF) induces the lymphocytes from C3HeB/FeJ lipopolysaccharide (LPS)-sensitive mice to produce adrenocorticotropin (ACTH) 1-39 and β-endorphin, whereas LPS induces these lymphocytes to produce ACTH 1-23 to 26 and α- or γ-endorphin. We have proposed that the smaller species of ACTH and endorphin are proteolytic cleavage products from ACTH 1-39 and β-endorphin analysis of C3HeB/FeJ LPS-treatment B lymphocyte lysates showed an enzymatic activity at pH 5 but not pH 7 that cleaved ACTH 1-39 into a smaller ACTH 1-23 to 26. The B lymphocytes from C3HeB/FeJ (LPS-resistant) mice expressed but did not process proopiomelanocortin after LPS or CRF treatment, nor did their B cells express the aforementioned enzymatic activity. Taken together, these data suggest a unique processing pathway in LPS-treated B lymphocytes and one in which immunoreactive (ir)-endorphins may play a role in the pathophysiology of endotoxic shock." @default.
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- W2005734679 date "1987-01-01" @default.
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- W2005734679 title "Novel processing pathway for proopiomelanocortin in lymphocytes: Endotoxin induction of a new prohormone-Cleaving enzyme" @default.
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- W2005734679 doi "https://doi.org/10.1002/jnr.490180116" @default.
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