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- W2005751639 abstract "Abstract Natural killer T (NKT) cells are potent immune modulators after stimulation with glycolipid ligand such as alpha-galactosylceramide (alpha-GC) through a rapid and massive production of a variety of cytokines such as IFN-gamma and IL-4. OCH, a sphingosine-truncated analogue of alpha-GC, induces the selective production of Th2 cytokines from NKT cells and inhibits Th1-mediated autoimmune disease models such as experimental autoimmune encephalomyelitis, type I diabetes and arthritis. The selective induction of Th2 cytokines is due to its unstable binding to CD1d and a short-lived stimulation to NKT cells which result in insufficient induction of c-Rel protein and following low level of IFN-gamma production. OCH induces less IFN-gamma production not only by NKT cells but also by NK cells due to an insufficient IL-12 production from dendritic cells. Lack of efficient IFN-gamma production and CD40L expression by NKT cells stimulated with OCH exert marginal IL-12 production by dendritic cells." @default.
- W2005751639 created "2016-06-24" @default.
- W2005751639 creator A5024919361 @default.
- W2005751639 date "2005-11-01" @default.
- W2005751639 modified "2023-09-25" @default.
- W2005751639 title "Potential of targeting natural killer T cells for the treatment of autoimmune diseases" @default.
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- W2005751639 doi "https://doi.org/10.1016/j.ics.2005.07.092" @default.
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