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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005752022> ?p ?o ?g. }

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• W2005752022 abstract "Therapeutic plasma exchange (TPE) – combined with medical immunomodulatory regimes – is conventionally defined as a disease-modifying apheretic approach. The purpose of TPE is to reduce the patient's load with damaging autoantibodies, immune-complexes, excessive metabolites and other injurious agents to the level that will allow for positive clinical outcome. The main disadvantage of standard TPE is the lack of “depletion selectivity” [ 1 Balint B. Ostojic G. Pavlovic M. Hrvacevic R. Pavlovic M. Tukic L. et al. Cytapheresis in the treatment of cell-affected blood disorders and abnormalities. Transfus Apher Sci. 2006; 35: 25-31 Abstract Full Text Full Text PDF PubMed Scopus (15) Google Scholar , 2 Szczepiorkowski Z. Winters J. Bandarenko N. Kim H. Linenberger M. Marques M. et al. Guidelines on the use of therapeutic apheresis in clinical practice – evidence-based approach from the Apheresis Applications Committee of the American Society for Apheresis. J Clin Apher. 2010; 25: 83-177 Crossref PubMed Scopus (450) Google Scholar ]. The aim of therapeutic cytapheresis is to reduce the cell count and hyperviscosity, as well as to replace the altered cellular division with normal (donor) cells. The goal of leukapheresis is the depletion of excessive circulating white blood cell (WBC) count, reversion of leukostasis caused by hyperleukocytosis (hemorheological repair), as well as prevention/reduction of the tumor lysis syndrome and hyperuricemia. Hyperleukocytosis is characterized as a circulating WBC or leukemic cell count ≥100 × 109/L. Typically, one single leukapheresis can reduce the WBC count by 30–50% [ [1] Balint B. Ostojic G. Pavlovic M. Hrvacevic R. Pavlovic M. Tukic L. et al. Cytapheresis in the treatment of cell-affected blood disorders and abnormalities. Transfus Apher Sci. 2006; 35: 25-31 Abstract Full Text Full Text PDF PubMed Scopus (15) Google Scholar ]. Finally, red blood cell (RBC) support should be avoided in patients with leukostasis prior to cytoreduction because of the risk of increasing hyperviscosity. The reason for RBC exchange (RBCX) is the replacement of altered or damaged cells with normal RBCs, followed by correction of anemia, which results frequently in long-term beneficial effects [ 1 Balint B. Ostojic G. Pavlovic M. Hrvacevic R. Pavlovic M. Tukic L. et al. Cytapheresis in the treatment of cell-affected blood disorders and abnormalities. Transfus Apher Sci. 2006; 35: 25-31 Abstract Full Text Full Text PDF PubMed Scopus (15) Google Scholar , 2 Szczepiorkowski Z. Winters J. Bandarenko N. Kim H. Linenberger M. Marques M. et al. Guidelines on the use of therapeutic apheresis in clinical practice – evidence-based approach from the Apheresis Applications Committee of the American Society for Apheresis. J Clin Apher. 2010; 25: 83-177 Crossref PubMed Scopus (450) Google Scholar ]." @default.
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• W2005752022 date "2015-04-01" @default.
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• W2005752022 title "Apheretic “rescue-protocol” designed for treatment of CLL associated life-threatening hemolytic crisis" @default.
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• W2005752022 doi "https://doi.org/10.1016/j.transci.2014.12.024" @default.
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