FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005755000> ?p ?o ?g. }

• W2005755000 endingPage "5462" @default.
• W2005755000 startingPage "5449" @default.
• W2005755000 abstract "Ni-containing superoxide dismutase (NiSOD) is the most recently discovered member of the class of metalloenzymes that detoxify the superoxide radical in aerobic organisms. In this study, we have employed a variety of spectroscopic and computational methods to probe the electronic structure of the NiSOD active site in both its oxidized (NiSOD(ox), possessing a low-spin (S = (1)/(2)) Ni(3+) center) and reduced (NiSOD(red), containing a diamagnetic Ni(2+) center) states. Our experimentally validated computed electronic-structure description for NiSOD(ox) reveals strong sigma-bonding interactions between Ni and the equatorial S/N ligands, which give rise to intense charge-transfer transitions in the near-UV region of the absorption spectrum. Resonance Raman (rR) spectra obtained with laser excitation in this region exhibit two features at 349 and 365 cm(-)(1) that are assigned to Ni-S(Cys) stretching modes. The NiSOD(red) active site also exhibits a high degree of metal-ligand bond covalency as well as filled/filled pi-interactions between Ni and S/N orbitals, which serve to adjust the redox potential of the Ni(2+) center. Comparison of our computational results for NiSOD(red) with those obtained in parallel studies of synthetic [NiS(2)N(2)] complexes reveals that the presence of an anionic N-donor ligand is crucial for promoting metal-based (versus S-based) oxidation of the active site. The implications of our electronic-structure descriptions with respect to the function of NiSOD are discussed, and a comparison of M-S(Cys) bonding in NiSOD and other metalloenzymes with sulfur ligation is provided." @default.
• W2005755000 created "2016-06-24" @default.
• W2005755000 creator A5063693103 @default.
• W2005755000 creator A5071606761 @default.
• W2005755000 creator A5078483518 @default.
• W2005755000 creator A5084381111 @default.
• W2005755000 date "2005-03-25" @default.
• W2005755000 modified "2023-10-03" @default.
• W2005755000 title "Spectroscopic and Computational Studies of Ni Superoxide Dismutase: Electronic Structure Contributions to Enzymatic Function" @default.
• W2005755000 cites W1965811107 @default.
• W2005755000 cites W1974493671 @default.
• W2005755000 cites W1977160384 @default.
• W2005755000 cites W1978651261 @default.
• W2005755000 cites W1980180610 @default.
• W2005755000 cites W1985228640 @default.
• W2005755000 cites W1986037798 @default.
• W2005755000 cites W1993774897 @default.
• W2005755000 cites W1995639502 @default.
• W2005755000 cites W1996786961 @default.
• W2005755000 cites W1998613997 @default.
• W2005755000 cites W2011393869 @default.
• W2005755000 cites W2013226985 @default.
• W2005755000 cites W2015365491 @default.
• W2005755000 cites W2016800344 @default.
• W2005755000 cites W2020114693 @default.
• W2005755000 cites W2020629753 @default.
• W2005755000 cites W2022040665 @default.
• W2005755000 cites W2023271753 @default.
• W2005755000 cites W2024374247 @default.
• W2005755000 cites W2027140236 @default.
• W2005755000 cites W2028125440 @default.
• W2005755000 cites W2029976844 @default.
• W2005755000 cites W2030687437 @default.
• W2005755000 cites W2031591672 @default.
• W2005755000 cites W2033306359 @default.
• W2005755000 cites W2034345411 @default.
• W2005755000 cites W2036815970 @default.
• W2005755000 cites W2038533471 @default.
• W2005755000 cites W2040891489 @default.
• W2005755000 cites W2045115052 @default.
• W2005755000 cites W2049774299 @default.
• W2005755000 cites W2052019092 @default.
• W2005755000 cites W2053792954 @default.
• W2005755000 cites W2055230539 @default.
• W2005755000 cites W2058231644 @default.
• W2005755000 cites W2061395334 @default.
• W2005755000 cites W2061700892 @default.
• W2005755000 cites W2065411687 @default.
• W2005755000 cites W2066611789 @default.
• W2005755000 cites W2068568687 @default.
• W2005755000 cites W2072631366 @default.
• W2005755000 cites W2076316855 @default.
• W2005755000 cites W2078146328 @default.
• W2005755000 cites W2079960377 @default.
• W2005755000 cites W2083636496 @default.
• W2005755000 cites W2084135044 @default.
• W2005755000 cites W2088894573 @default.
• W2005755000 cites W2093482288 @default.
• W2005755000 cites W2114443210 @default.
• W2005755000 cites W2124749781 @default.
• W2005755000 cites W2142647742 @default.
• W2005755000 cites W2402288051 @default.
• W2005755000 cites W2949913820 @default.
• W2005755000 cites W2950216492 @default.
• W2005755000 cites W3026506360 @default.
• W2005755000 cites W336484121 @default.
• W2005755000 doi "https://doi.org/10.1021/ja042521i" @default.
• W2005755000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15826182" @default.
• W2005755000 hasPublicationYear "2005" @default.
• W2005755000 type Work @default.
• W2005755000 sameAs 2005755000 @default.
• W2005755000 citedByCount "101" @default.
• W2005755000 countsByYear W20057550002012 @default.
• W2005755000 countsByYear W20057550002013 @default.
• W2005755000 countsByYear W20057550002014 @default.
• W2005755000 countsByYear W20057550002015 @default.
• W2005755000 countsByYear W20057550002016 @default.
• W2005755000 countsByYear W20057550002017 @default.
• W2005755000 countsByYear W20057550002018 @default.
• W2005755000 countsByYear W20057550002020 @default.
• W2005755000 countsByYear W20057550002021 @default.
• W2005755000 countsByYear W20057550002022 @default.
• W2005755000 countsByYear W20057550002023 @default.
• W2005755000 crossrefType "journal-article" @default.
• W2005755000 hasAuthorship W2005755000A5063693103 @default.
• W2005755000 hasAuthorship W2005755000A5071606761 @default.
• W2005755000 hasAuthorship W2005755000A5078483518 @default.
• W2005755000 hasAuthorship W2005755000A5084381111 @default.
• W2005755000 hasConcept C115260700 @default.
• W2005755000 hasConcept C115624301 @default.
• W2005755000 hasConcept C116569031 @default.
• W2005755000 hasConcept C120665830 @default.
• W2005755000 hasConcept C121332964 @default.
• W2005755000 hasConcept C139358910 @default.
• W2005755000 hasConcept C147120987 @default.
• W2005755000 hasConcept C147597530 @default.
• W2005755000 hasConcept C155860418 @default.
• W2005755000 hasConcept C170493617 @default.

• next