Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005757613> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2005757613 abstract "Overexpression of HER2 (ErbB2) oncoprotein is associated with approximately 25% of aggressive breast carcinoma. Although a humanized monoclonal antibody (Trastuzumab) against HER2 is currently considered one of the most effective treatments, a significant number of patients are initially or eventually become resistant to Trastuzumab based therapy. Here, we demonstrate that secreted phosphoglucose isomerase (PGI)/ autocrine motility factor (AMF), an orphan -CXXC- cytokine directly binds to HER2 and activates PI3K and MAPK through HER2 autophosphorylation, and also induces immediately HER2 cleavage in metalloprotease dependent fashion. We therefore speculate that AMF/HER2 signaling pathways play a physiological role in HER2 overexpressing breast cancer cells and contribute to Trastuzumab resistance and propose that AMF can be a novel therapeutic target in Trastuzumab resistant breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1079. doi:1538-7445.AM2012-1079" @default.
- W2005757613 created "2016-06-24" @default.
- W2005757613 creator A5068190334 @default.
- W2005757613 date "2012-04-15" @default.
- W2005757613 modified "2023-09-25" @default.
- W2005757613 title "Abstract 1079: Identification of autocrine motility factor (AMF) receptor, HER2 (ErbB2) in breast cancer cells" @default.
- W2005757613 doi "https://doi.org/10.1158/1538-7445.am2012-1079" @default.
- W2005757613 hasPublicationYear "2012" @default.
- W2005757613 type Work @default.
- W2005757613 sameAs 2005757613 @default.
- W2005757613 citedByCount "0" @default.
- W2005757613 crossrefType "proceedings-article" @default.
- W2005757613 hasAuthorship W2005757613A5068190334 @default.
- W2005757613 hasConcept C121608353 @default.
- W2005757613 hasConcept C126322002 @default.
- W2005757613 hasConcept C128240485 @default.
- W2005757613 hasConcept C170493617 @default.
- W2005757613 hasConcept C184235292 @default.
- W2005757613 hasConcept C2779786085 @default.
- W2005757613 hasConcept C502942594 @default.
- W2005757613 hasConcept C530470458 @default.
- W2005757613 hasConcept C57074206 @default.
- W2005757613 hasConcept C58207958 @default.
- W2005757613 hasConcept C71924100 @default.
- W2005757613 hasConcept C86803240 @default.
- W2005757613 hasConcept C95444343 @default.
- W2005757613 hasConcept C96232424 @default.
- W2005757613 hasConceptScore W2005757613C121608353 @default.
- W2005757613 hasConceptScore W2005757613C126322002 @default.
- W2005757613 hasConceptScore W2005757613C128240485 @default.
- W2005757613 hasConceptScore W2005757613C170493617 @default.
- W2005757613 hasConceptScore W2005757613C184235292 @default.
- W2005757613 hasConceptScore W2005757613C2779786085 @default.
- W2005757613 hasConceptScore W2005757613C502942594 @default.
- W2005757613 hasConceptScore W2005757613C530470458 @default.
- W2005757613 hasConceptScore W2005757613C57074206 @default.
- W2005757613 hasConceptScore W2005757613C58207958 @default.
- W2005757613 hasConceptScore W2005757613C71924100 @default.
- W2005757613 hasConceptScore W2005757613C86803240 @default.
- W2005757613 hasConceptScore W2005757613C95444343 @default.
- W2005757613 hasConceptScore W2005757613C96232424 @default.
- W2005757613 hasLocation W20057576131 @default.
- W2005757613 hasOpenAccess W2005757613 @default.
- W2005757613 hasPrimaryLocation W20057576131 @default.
- W2005757613 hasRelatedWork W1595480427 @default.
- W2005757613 hasRelatedWork W1990208211 @default.
- W2005757613 hasRelatedWork W1997105327 @default.
- W2005757613 hasRelatedWork W2013555468 @default.
- W2005757613 hasRelatedWork W2019088078 @default.
- W2005757613 hasRelatedWork W2067755608 @default.
- W2005757613 hasRelatedWork W2116177673 @default.
- W2005757613 hasRelatedWork W2149018167 @default.
- W2005757613 hasRelatedWork W2215207270 @default.
- W2005757613 hasRelatedWork W2281897907 @default.
- W2005757613 hasRelatedWork W2288696739 @default.
- W2005757613 hasRelatedWork W2331058833 @default.
- W2005757613 hasRelatedWork W2398682002 @default.
- W2005757613 hasRelatedWork W2741123349 @default.
- W2005757613 hasRelatedWork W2910837626 @default.
- W2005757613 hasRelatedWork W3008411981 @default.
- W2005757613 hasRelatedWork W3013826160 @default.
- W2005757613 hasRelatedWork W3035742543 @default.
- W2005757613 hasRelatedWork W3178005531 @default.
- W2005757613 hasRelatedWork W3195543529 @default.
- W2005757613 isParatext "false" @default.
- W2005757613 isRetracted "false" @default.
- W2005757613 magId "2005757613" @default.
- W2005757613 workType "article" @default.