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• W2005769596 abstract "Objective: Our purpose was to evaluate the efficacy and safety of 3 dosages of Esclim, delivering 0.025 mg, 0.050 mg, or 0.100 mg 17β-estradiol per 24 hours, in the treatment of moderate to severe vasomotor symptoms. Study Design: In this double-blind, placebo-controlled, parallel-group, multicenter trial, 196 highly symptomatic menopausal women received 12 weeks of continuous unopposed treatment with 1 of the 3 dosages of Esclim or a matching placebo patch. Results: The reduction in frequency of moderate to severe vasomotor symptoms was statistically significant compared with placebo (P < .05) from week 2 onward in the Esclim 50 and 100 groups and from week 3 onward in the Esclim 25 group. Symptom severity was also reduced. Estrogen-related adverse events, particularly metrorrhagia and endometrial hyperplasia, were less frequent in the Esclim 25 group than in the higher-dosage groups. Conclusion: All 3 dosages of Esclim were effective in the treatment of vasomotor symptoms. The efficacy and safety of Esclim 25 indicate a good risk-benefit ratio. (Am J Obstet Gynecol 1999;181:71-9.)" @default.
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• W2005769596 date "1999-07-01" @default.
• W2005769596 modified "2023-09-27" @default.
• W2005769596 title "Efficacy and safety of low, standard, and high dosages of an estradiol transdermal system (Esclim) compared with placebo on vasomotor symptoms in highly symptomatic menopausal patients" @default.
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• W2005769596 doi "https://doi.org/10.1016/s0002-9378(99)70438-2" @default.
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