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• W2005771927 startingPage "242" @default.
• W2005771927 abstract "Nociceptin (NOC), an endogenous ligand for the orphan opioid receptor ORL1 (ORL1), has recently been recognized as a neuropeptide. We used brain microdialysis and on-line high performance liquid chromatography (HPLC) to examine the effect of NOC on the basal outflow of acetylcholine (ACh) in the freely moving rat striatum in vivo. ACh release was reduced by nociceptin at a concentration of 10(-5) M to 79% of control release. This effect of NOC was attenuated by [Phe1Psi(CH2-NH)Gly2]nociceptin-(1-13)-NH2 (PhePsi), suggesting that NOC activates the ORL1 receptor and (PhePsi) acts as an antagonist on ORL1 in rat striatum in vivo. These findings indicate that NOC may act as a neuropeptide which inhibits ACh release in the striatum via ORL1." @default.
• W2005771927 created "2016-06-24" @default.
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• W2005771927 date "1999-10-01" @default.
• W2005771927 modified "2023-10-02" @default.
• W2005771927 title "Modification of acetylcholine release by nociceptin in conscious rat striatum" @default.
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• W2005771927 doi "https://doi.org/10.1016/s0006-8993(99)01954-x" @default.
• W2005771927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10536205" @default.
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