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• W2005776651 startingPage "187" @default.
• W2005776651 abstract "Four areas in the late embryonic murine forebrain, i.e. the subpallium (striatum), the preoptic region, the ventral thalamus, and the hypothalamus, have been described to express the basic helix–loop–helix (bHLH) gene mammalian achaete-scute homolog Mash1 (Ascl1, Mouse Genome Informatics) in a complementary fashion to another bHLH gene, neurogenin1 (ngn1) (Neurod3, Mouse Genome Informatics), which is expressed in directly adjacent forebrain regions. We report here that the four regions previously identified as subpallium, preoptic region, ventral thalamus and hypothalamus (i.e. ventral inferior lobe) in the postembryonic zebrafish brain show Zash-1a expression at 3 days postfertilization (dpf), whereas none of those areas express the bHLH gene neuroD (nrd) between 2 and 5 dpf. This indicates that two well established alternative genetic pathways involved in neurogenesis in the amniote (mammalian) brain are present in homologous phenotypic locations in the anamniote (zebrafish) brain as well and that these pathways possibly act similarly in the generation of different neuronal phenotypes (e.g. subpallial GABAergic interneurons versus pallial glutamatergic projection neurons, or dopaminergic neurons versus other neurotransmitter phenotypes). Furthermore, previous initial identification of early postembryonic brain subdivisions in the zebrafish is strongly corroborated by these expression patterns." @default.
• W2005776651 created "2016-06-24" @default.
• W2005776651 creator A5022846156 @default.
• W2005776651 creator A5045190731 @default.
• W2005776651 date "2002-10-01" @default.
• W2005776651 modified "2023-10-11" @default.
• W2005776651 title "Expression of Zash-1a in the postembryonic zebrafish brain allows comparison to mouse Mash1 domains" @default.
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• W2005776651 doi "https://doi.org/10.1016/s1567-133x(02)00016-9" @default.
• W2005776651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12638130" @default.
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