FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005779329> ?p ?o ?g. }

• W2005779329 endingPage "30" @default.
• W2005779329 startingPage "18" @default.
• W2005779329 abstract "A major obstacle to the use of adenovirus as a vector for gene therapy is the host immune response to hexon, the major protein component of the icosahedral capsid. A solution lies in creating novel vectors with modified or chimeric hexons to evade the immune response to native hexon. The crystal structure of hexon from human adenovirus type 5 (ad5), the type primarily used for gene therapy, has been determined to facilitate the design of such molecules. As the 951-amino-acid (aa) ad5 hexon sequence is closely related to that of ad2 (967 aa; 86% aa identity), the ad5 structure was solved by molecular replacement with a model constructed from the known ad2 hexon. During refinement, greater than 25% of the sequence was reassigned, resulting in a relocation of two epitope regions, from buried positions in the ad2 model to external sites at the top of the ad5 molecule. The resultant model is in better agreement with crystallographic data, while maintaining the overall topology of ad2 hexon. This work suggests that all hexons have the same basic fold and that the ad5 hexon structure provides an accurate and representative model for designing new adenovirus vectors." @default.
• W2005779329 created "2016-06-24" @default.
• W2005779329 creator A5013314193 @default.
• W2005779329 creator A5057157823 @default.
• W2005779329 date "2000-01-01" @default.
• W2005779329 modified "2023-10-13" @default.
• W2005779329 title "Type-Specific Epitope Locations Revealed by X-Ray Crystallographic Study of Adenovirus Type 5 Hexon" @default.
• W2005779329 cites W1499557928 @default.
• W2005779329 cites W1546896179 @default.
• W2005779329 cites W1551355794 @default.
• W2005779329 cites W1558908218 @default.
• W2005779329 cites W1606292520 @default.
• W2005779329 cites W1908149672 @default.
• W2005779329 cites W1940378630 @default.
• W2005779329 cites W1971149301 @default.
• W2005779329 cites W1972244141 @default.
• W2005779329 cites W1975725195 @default.
• W2005779329 cites W1980196242 @default.
• W2005779329 cites W1981317956 @default.
• W2005779329 cites W1983594724 @default.
• W2005779329 cites W1984386894 @default.
• W2005779329 cites W1985696897 @default.
• W2005779329 cites W1989669523 @default.
• W2005779329 cites W1996607909 @default.
• W2005779329 cites W1998149067 @default.
• W2005779329 cites W2001575235 @default.
• W2005779329 cites W2003576860 @default.
• W2005779329 cites W2004104814 @default.
• W2005779329 cites W2007164713 @default.
• W2005779329 cites W2008089465 @default.
• W2005779329 cites W2013083986 @default.
• W2005779329 cites W2021126788 @default.
• W2005779329 cites W2021854607 @default.
• W2005779329 cites W2026956259 @default.
• W2005779329 cites W2028231353 @default.
• W2005779329 cites W2032078031 @default.
• W2005779329 cites W2046502532 @default.
• W2005779329 cites W2049521571 @default.
• W2005779329 cites W2051758487 @default.
• W2005779329 cites W2057984729 @default.
• W2005779329 cites W2061657917 @default.
• W2005779329 cites W2064370480 @default.
• W2005779329 cites W2077317257 @default.
• W2005779329 cites W2080528351 @default.
• W2005779329 cites W2088967123 @default.
• W2005779329 cites W2093525750 @default.
• W2005779329 cites W2095232193 @default.
• W2005779329 cites W2098547117 @default.
• W2005779329 cites W2116071714 @default.
• W2005779329 cites W2122037691 @default.
• W2005779329 cites W2123745267 @default.
• W2005779329 cites W2126816581 @default.
• W2005779329 cites W2127481689 @default.
• W2005779329 cites W2131095976 @default.
• W2005779329 cites W2133822846 @default.
• W2005779329 cites W2140376045 @default.
• W2005779329 cites W2143760524 @default.
• W2005779329 cites W2151687360 @default.
• W2005779329 cites W2154334620 @default.
• W2005779329 cites W2161743998 @default.
• W2005779329 cites W2168211076 @default.
• W2005779329 cites W2322389503 @default.
• W2005779329 cites W2328476123 @default.
• W2005779329 cites W25512870 @default.
• W2005779329 cites W64861853 @default.
• W2005779329 doi "https://doi.org/10.1006/mthe.1999.0001" @default.
• W2005779329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10933908" @default.
• W2005779329 hasPublicationYear "2000" @default.
• W2005779329 type Work @default.
• W2005779329 sameAs 2005779329 @default.
• W2005779329 citedByCount "142" @default.
• W2005779329 countsByYear W20057793292012 @default.
• W2005779329 countsByYear W20057793292013 @default.
• W2005779329 countsByYear W20057793292014 @default.
• W2005779329 countsByYear W20057793292015 @default.
• W2005779329 countsByYear W20057793292016 @default.
• W2005779329 countsByYear W20057793292017 @default.
• W2005779329 countsByYear W20057793292018 @default.
• W2005779329 countsByYear W20057793292019 @default.
• W2005779329 countsByYear W20057793292020 @default.
• W2005779329 countsByYear W20057793292021 @default.
• W2005779329 countsByYear W20057793292022 @default.
• W2005779329 countsByYear W20057793292023 @default.
• W2005779329 crossrefType "journal-article" @default.
• W2005779329 hasAuthorship W2005779329A5013314193 @default.
• W2005779329 hasAuthorship W2005779329A5057157823 @default.
• W2005779329 hasBestOaLocation W20057793291 @default.
• W2005779329 hasConcept C104317684 @default.
• W2005779329 hasConcept C111599444 @default.
• W2005779329 hasConcept C153911025 @default.
• W2005779329 hasConcept C159047783 @default.
• W2005779329 hasConcept C159654299 @default.
• W2005779329 hasConcept C167625842 @default.
• W2005779329 hasConcept C195616568 @default.
• W2005779329 hasConcept C202878990 @default.
• W2005779329 hasConcept C2522874641 @default.
• W2005779329 hasConcept C2776954459 @default.
• W2005779329 hasConcept C2777046247 @default.

• next