Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005780557> ?p ?o ?g. }
- W2005780557 endingPage "461" @default.
- W2005780557 startingPage "453" @default.
- W2005780557 abstract "Gamma-aminobutyric acid type A (GABA(A)) receptors in brain adapt to chronic ethanol exposure via changes in receptor function and subunit expression. The present review summarizes currently available data regarding changes in GABA(A) receptor subunit mRNA and peptide expression. Data are presented from various different brain regions and the variations between specific brain regions used to draw conclusions about mechanisms that may underlie GABA(A) receptor adaptations during chronic ethanol exposure. In the whole cerebral cortex, chronic ethanol exposure leads to a reduction of GABA(A) receptor alpha1 subunit mRNA and peptide levels and a near equivalent increase in alpha4 subunit mRNA and peptide levels. This observation is the primary support for the hypothesis that altered receptor composition is a mechanism for GABA(A) receptor adaptation produced by chronic ethanol exposure. However, other brain regions do not display similar patterns of subunit changes. Moreover, subregions within cortex (prefrontal, cingulate, parietal, motor, and piriform) exhibit patterns of changes in subunit expression that differ from whole cortex. Therefore, regional differences in GABA(A) receptor subunit expression are evident following chronic ethanol administration, thus suggesting that multiple mechanisms contribute to the regulation of GABA(A) receptor expression. These mechanisms may include the involvement of other neurotransmitter systems, endogenous steroids and second or third messenger cross-talk." @default.
- W2005780557 created "2016-06-24" @default.
- W2005780557 creator A5020398019 @default.
- W2005780557 creator A5024081434 @default.
- W2005780557 creator A5076989037 @default.
- W2005780557 date "2000-11-01" @default.
- W2005780557 modified "2023-10-17" @default.
- W2005780557 title "Regional variations in the effects of chronic ethanol administration on GABAA receptor expression: potential mechanisms" @default.
- W2005780557 cites W145363236 @default.
- W2005780557 cites W1522904635 @default.
- W2005780557 cites W1626578772 @default.
- W2005780557 cites W1922154348 @default.
- W2005780557 cites W1964597276 @default.
- W2005780557 cites W1973649857 @default.
- W2005780557 cites W1978399465 @default.
- W2005780557 cites W1980333362 @default.
- W2005780557 cites W1980527519 @default.
- W2005780557 cites W1980844720 @default.
- W2005780557 cites W1983967908 @default.
- W2005780557 cites W1992465786 @default.
- W2005780557 cites W1995357866 @default.
- W2005780557 cites W1998624786 @default.
- W2005780557 cites W1998971005 @default.
- W2005780557 cites W1999287710 @default.
- W2005780557 cites W2000062266 @default.
- W2005780557 cites W2009095856 @default.
- W2005780557 cites W2011010786 @default.
- W2005780557 cites W2014742554 @default.
- W2005780557 cites W2015229056 @default.
- W2005780557 cites W2015237297 @default.
- W2005780557 cites W2018769555 @default.
- W2005780557 cites W2019873672 @default.
- W2005780557 cites W2028970380 @default.
- W2005780557 cites W2032681902 @default.
- W2005780557 cites W2032709032 @default.
- W2005780557 cites W2032841846 @default.
- W2005780557 cites W2034812041 @default.
- W2005780557 cites W2035108543 @default.
- W2005780557 cites W2039738625 @default.
- W2005780557 cites W2044417747 @default.
- W2005780557 cites W2045355683 @default.
- W2005780557 cites W2048406255 @default.
- W2005780557 cites W2057168832 @default.
- W2005780557 cites W2059146457 @default.
- W2005780557 cites W2063939591 @default.
- W2005780557 cites W2064492505 @default.
- W2005780557 cites W2066394439 @default.
- W2005780557 cites W2072214718 @default.
- W2005780557 cites W2072614922 @default.
- W2005780557 cites W2075605490 @default.
- W2005780557 cites W2076501023 @default.
- W2005780557 cites W2076787408 @default.
- W2005780557 cites W2077488853 @default.
- W2005780557 cites W2087045924 @default.
- W2005780557 cites W2093117551 @default.
- W2005780557 cites W2103336557 @default.
- W2005780557 cites W2108264967 @default.
- W2005780557 cites W2117614741 @default.
- W2005780557 cites W2117770051 @default.
- W2005780557 cites W2118838905 @default.
- W2005780557 cites W2119479764 @default.
- W2005780557 cites W2126000479 @default.
- W2005780557 cites W2128692167 @default.
- W2005780557 cites W2144863637 @default.
- W2005780557 cites W2154521977 @default.
- W2005780557 cites W2156475624 @default.
- W2005780557 cites W2160614601 @default.
- W2005780557 cites W2164412530 @default.
- W2005780557 cites W4249618565 @default.
- W2005780557 doi "https://doi.org/10.1016/s0197-0186(00)00058-9" @default.
- W2005780557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10871697" @default.
- W2005780557 hasPublicationYear "2000" @default.
- W2005780557 type Work @default.
- W2005780557 sameAs 2005780557 @default.
- W2005780557 citedByCount "56" @default.
- W2005780557 countsByYear W20057805572012 @default.
- W2005780557 countsByYear W20057805572014 @default.
- W2005780557 countsByYear W20057805572015 @default.
- W2005780557 countsByYear W20057805572016 @default.
- W2005780557 countsByYear W20057805572018 @default.
- W2005780557 countsByYear W20057805572023 @default.
- W2005780557 crossrefType "journal-article" @default.
- W2005780557 hasAuthorship W2005780557A5020398019 @default.
- W2005780557 hasAuthorship W2005780557A5024081434 @default.
- W2005780557 hasAuthorship W2005780557A5076989037 @default.
- W2005780557 hasConcept C104292427 @default.
- W2005780557 hasConcept C104317684 @default.
- W2005780557 hasConcept C126322002 @default.
- W2005780557 hasConcept C134018914 @default.
- W2005780557 hasConcept C168258287 @default.
- W2005780557 hasConcept C169760540 @default.
- W2005780557 hasConcept C170493617 @default.
- W2005780557 hasConcept C185592680 @default.
- W2005780557 hasConcept C2776674594 @default.
- W2005780557 hasConcept C55493867 @default.
- W2005780557 hasConcept C71924100 @default.
- W2005780557 hasConcept C86803240 @default.
- W2005780557 hasConcept C9224880 @default.